Road Block

To reach such a site, a molecule must permeate through many road blocks formed by cell membranes. These are composed of phospholipid bilayers - oily barriers that greatly attenuate the passage of charged or highly polar molecules. Often, cultured cells, such as Caco-2 or Madin-Darby canine kidney (MDCK) cells [1-4], are used for this purpose, but the tests are costly. Other types of permeability measurements based on artificial membranes have been considered, the aim being to improve efficiency and lowering costs. One such approach, PAMPA, has been described by Kansy et al. [5],... 

The road block and sharp stop were unexpected the storm of gunfire, glass and blood in the enclosed confines of the car were enough to break even Trix s nerve in an instant. The hammer of boots on the bonnet and roof as someone vaulted swiftly up to fire on the car behind barely registered. Her heart was going ninety-to-the-dozen, her mind racing to catch up, as the Colonel shoved her head low, then shielded her with his own body. A warmer brand of surprise to counter the chill of shock. 

Organizations often assume they know themselves inside-out and fail to acknowledge white spots. In particular, mindsets and attitudes important for change programs are often not fully understood. A diagnostic makes the performance culture transparent and identifies possible performance gaps and road blocks. 

The borders between European countries are equipped with movable road blocks that resemble the fold-r ing gates often used to prevent toddlers from falling down stairs or from entering off-limits rooms.The device has a sharpened spike at each pivot point and is anchored at one side of the road. A guard extends the obstacle into one or both lanes to block the road, and folds it out of the way to allow authorized vehicles to pass. 

The deadening chill of formalism is as fatal to good indexing of facts as it is to worship. The letter kills the spirit gives life. Dynamic subject heading lists are compiled, maintained, and administered with informed skill and care as potent instruments for better indexing and potent aids to skilled searchers. Static subject heading lists, compiled and administered under slavish adherence to a frozen set of rules, are road blocks. 

The STM tip can also be used for nanomanipulation. In fact the first atomic level nanomanipulation was done by STM only [91]. However, in more recent context, by nanomanipulation we generally imply use of an AFM cantilever to manipulate nano-objects. This field, however, is in its early stages and there is a need to understand the physics of the manipulation in terms of the basic forces that are involved in this process. It is realized that it is different from what one sees in micromanipulation. There are three main road blocks that need to be solved effectively before this field can mature. First, there is the need to understand the basic physical and chemical processes that take place at the scale of a few nanometers, including the mechanics. Second, one need to develop effective hardware as well as control that has resolution and reproducibility of manipulation at this level. Third, there is a need for effective automation and software. Interestingly, these road-... 

In addition to these road-block charges, a number of 10-foot planks should be prepared with the appropriate quantity of explosive strapped to them. These portable ro charges can be rushed to any threatened point and laid by the roadside suitably concealed. On the approach of tanks or armoured fighting vehicles these planks can be dragged across the road and expired under the vehicle as required. 

In considering development and implementation of a framework, it is important also to be aware of potential road blocks to success, namely Is the profession ready . Is there other work that needs to be done first Has enough of the background work been done to start implementing something that will be useful or successful over the next 3-5 years With such a rapid pace of change, will anything conceived today have relevance tomorrow ... 

I m sure you ve seen movies and TV shows where road blocks are put up and the villain or hero crashes right through and gets away. This is for effect, as decently equipped police departments have portable road blocks studded with over siied spikes. For P.D.s who can t affort these or need to stop traffic immediately without calling in, you can t beat my tire shredding road blocks. They can also be used by civilians to teach trespassers the error of their ways. 

Pulse-chase/pulse-quench experiments with KF ° indicated accumulation of the nucleotide bound enzyme species, which would not be possible if the forward reaction was much faster than the rate of conformational closing. To explain this observation, the authors proposed the presence of a kinetic road block - a slow step after the phosphodiester bond formation. However, the results of the pulse-chase/ pulse-quench experiments can also be explained by designating chemistry as the slow step, meaning that the chemical step itself plays the role of the road block. The conclusion that chemistry is a fast step in the KF reaction pathway was made based on the observation of a small thio-efifect magnitude,which, as elaborated in the following section, should not be used as a solid evidence of the chemical step being nonrate limiting. 

Driving back into Tel Aviv, we were stopped three times at road blocks, where passes were examined and the car searched each time for explosives. A special security order had been issued. Some damned rumor, grumbled Rabinowicz. It happens all the time. But you can t blame em. If they start taking chances somebody will sneak by with a load of dynamite one of these days and blow up half of Tel Aviv. ... 

We pulled up at a road block manned by soldiers of the Arab Legion. This was my first sight of these Transjordan troops. They looked rather dirty, and their spiked helmets rather incongruous over their dark Arab faces. The driver showed his vehicle pass and started to drive on. The Arab sergeant pointed at me and said something—evidently he wanted to know why a man in civilian clothes was riding in a police car. 

We rolled up to a road block, manned by perhaps half a dozen men. A noncommissioned offiicer, eying the American... 

Scherkenbach WW, The Deeming Route to Quality and Productivity, Road Maps and Road Blocks, CEE Press Books, Washington DC, 1986. 

The need of a column with equivalent selectivity but smaller particle size and shorter length as a possible road block is removed. 

More powers to police (road blocks, tear gas, dogs, 28% commando equipment, fire hoses, etc.)... 

Further power to be given to the police by using road blocks to intercept troublemakers an extension of the Vagrancy Act to... 

Progress and Road Blocks in the Development of Carbon Nanotubes as Cellular Carriers for Nucleic Acids... 

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