RNA binding motifs

Multinuclear and Cocatalytic Zinc Enzymes.. . Zinc Fingers - DNA- and RNA-Binding Motifs References. 

DSRM Double-stranded RNA binding motif E(MFP)B 2(2) 12(19) 1STU... 

Gribskov, M. (1992). Translational initiation factors IF-1 and eIF-2 alpha share an RNA-binding motif with prokaryotic ribosomal protein SI and polynucleotide phosphoryl-ase. Gene 119, 107-111. 

Dempsey LA, Hanakahi LA, Maizels N (1998) A specific isoform of hnRNP D interacts with DNA in the LRl heterodimer canonical RNA binding motifs in a sequence-specific duplex DNA binding protein. J Biol Chem 273 29224-29229... 

RNA binding motif protein 8A Reticulocalbin Thioredoxin peroxidase Transgelin (SM22-alpha) Transmembrane protein 4 Tropomyosin alpha 4 chain Tubulin alpha-1 chain Tubulin beta-5 chain Ubiquitin C-terminal esterase Tropomyosin isoform 1... 

RNA binding motif protein 8A, and others in ESCC tissues. Table 2 shows the summary of the proteins whose expression was different between esophageal eaneer tissues and non-cancerous tissues. 

The precise manner in which proteins with zinc fingers bind to DNA differs from one protein to the next. Some zinc fingers contain the amino acid residues that are important in sequence discrimination, whereas others appear to bind DNA nonspecifically (the amino acids required for specificity are located elsewhere in the protein). Zinc fingers can also function as RNA-binding motifs—for example, in certain proteins that bind eukaryotic mRNAs and act as translational repressors. We discuss this role later (Section 28.3). 

Braun, I.C., Rohrbach, E., Schmitt, C. and Izaurralde, E. (1999) TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. EMBOJ., 18, 1953-1965. 

Caban K, Kinzy SA, Copeland PR. The L7Ae RNA binding motif... 

RNA binding proteins are structurally very diverse. Most of the ribosomal proteins are devoid of recognizable RNA binding motifs, whereas, the evolution of proteins involved with RNA processing, such as hnRNA, mRNA and snRNA binding proteins, has resulted in several fairly conserved RNA binding motifs (Table 1.1). 

RNA-binding motif Actinin-type actin-binding motifs DNA-binding motifs Ribosomal-protein motifs Prokaryotic DNA-binding motifs N-myristoylation motif Amino acid composition... 

Like transcription factors, most hnRNP proteins have a modular structure. They contain one or more RNA-binding domains and at least one other domain that is thought to interact with other proteins. Several different RNA-binding motifs have been Identified by constructing deletions of hnRNP proteins and testing their ability to bind RNA. 

Conserved RNA-Binding Motifs The RNA recognition motif (RRM), also called the RNP motif and the RNA-... 

The RGG box, another RNA-binding motif found in hnRNP proteins, contains five Arg-Gly-Gly (RGG) repeats with several interspersed aromatic amino acids. Although the structure of this motif has not yet been determined, its arginine-rich nature is similar to the RNA-binding domains of the HIV Tat protein. The 45-resldue KH motif is found in the hnRNP K protein and several other RNA-binding proteins commonly two or more copies of the KH motif are Interspersed with RGG repeats. The three-dimensional structure of representative KH domains is similar to that of the RRM domain but smaller, consisting of a three-stranded p sheet supported from one side by two a helices. RNA binds to the KH motif by interacting with a hydrophobic surface formed by the a helices and one... 

THioUridine synthases, RNA Methyltransferases, and Pseudouridine synthases RNA-binding motif originally characterized in TRM2 and miaB... 

Tian, B., Bevilacqua, PC., Diegelman-Parente, A., Mathews, M.B. The double-stranded-RNA-binding motif Interference and much more. Nat. Rev. Mol. Cell Biol. 2004, 5,1013-23. 

Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L (2003) The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol 10 1026-1032... 

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