Rifampicin drug interactions

Egle H, Trittler 1 Kummerer K, Lemmen SW. Linezolid and rifampicin drug interaction contrary to expectations CUn Pharmacol Ther (2005) 77,451 -3. 

Heimark LD, Gibaldi Trager WF, O Reilty RA, Goulart DA The mechanism of the war-farin-rifampicin drug interaction in humans. Clin Pharmacol Ther (1987) 42,388-94. 

Takasugi T. A case of hypertension suggesting nifedipine and rifampicin drug interaction. Igaku To Yakugaku (1989) 22, 132-5. 

As far as sinusoidal uptake is concerned, drug-drug interactions have also been reported between antituberculosis agents (rifamycin SV and rifampicin) and bromosulfophthalein in humans both drugs reduce the clearance of bromosul-fophthalein and also induce hyperbilirubinemia [108]. These results may be ac-... 

There are some clinically important pharmacodynamic drug-drug interactions to be mentioned. Antipsychotics will potentiate the central depressant effects of sedatives and of alcohol. They will also increase the risk of respiratory-depressant effects of opiates. Inducers of drug metabolic enzymes like for example rifampicin and several antiepileptics, may increase the elimination rate of antipsychotic agents and thus decrease their efficacy. 

Drug Interactions Gemfibrozil Niacin Erythromycin Cholestyramine Digoxin Cimetidine/ranitidine/ omeprazole Rifampicin Warfarin Itraconazole Gemfibrozil Niacin Erythromycin Propranolol Digoxin Warfarin Antacids Colestipol Digoxin Erythromycin Oral contraceptives Fibrates Niacin Azole antifungals... 

Martin P et al (2011) Pharmacokinetic drug interactions with vandetanib during coadministration with rifampicin or itraconazole. Drugs R D 11 37-51... 

Jayasagar G, Krishna Kumar M, Chandrasekhar K, et al. Influence of rifampicin pretreatment on the pharmacokinetics of celecoxib in healthy male volunteers. Drug Metabol Drug Interact 2003 19(4) 287-295. 

Swaisland HC, Ranson M, Smith RP, et al. Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol. Clin Pharmacokinet 2005 44(10) 1067—1081. 

The drug interactions with rifampicin and ciprofloxacin would also need to be taken into account if hormonal methods were used [19, 36]. 

ALMOTRIPTAN, ELETRIPTAN CARBAMAZEPINE Possible 1 plasma concentrations of almotriptan and risk of inadequate therapeutic efficacy. Risk of serotonin syndrome One of the major metabolizing enzymes of almotriptan - CYP3A4 isoenzymes - is induced by rifampicin. As there are alternative metabolic pathways, the effect may not be significant and can vary from individual to individual. Triptans and carbamazepine are both stimulants of 5-HT receptors, and carbamazepine in addition prevents the reuptake of 5-HT Be aware of possibility of l response to triptan, and consider T dose if considered to be due to interaction. Be aware of the possibility of the occurrence of serotonin syndrome >- For signs and symptoms of serotonin toxicity, see Clinical Features of Some Adverse Drug Interactions, Serotonin toxicity and serotonin syndrome... 

SULPHONYLUREAS RIFAMPICIN 1 hypoglycaemic efficacy Plasma levels of sulphonylureas are J- by induction of CYP-mediated metabolism Watch for and warn patients about symptoms of hyperglycaemia - For signs and symptoms of hypoglycaemia, see Clinical Features of Some Adverse Drug Interactions, Hypoglycaemia... 

Pharmacokinetic interaction the drugs interact remotely from the target site to alter plasma (and other tissue) concentrations so that the amount of the drug at the target site of clinical effect is altered, e.g. enzyme induction by rifampicin will reduce the plasma concentration of warfarin enzyme inhibition by ciprofloxacin will elevate the concentration of theophylline. 

Balakrishnan, Seshadri PS. Drug interactions—the influence of rifampicin and clofazimine on the urinary excretion of DDS. Lepr India 1981 53(l) 17-22. 

Mathur A, Venkatesan K, Girdhar BK, Bharadwaj VP, Girdhar A, Bagga AK. A study of drug interactions in leprosy—1. Effect of simultaneous administration of prothionamide on metabolic disposition of rifampicin and dapsone. Lepr Rev 1986 57(l) 33-7. 

Some drug interactions with rifampicin have been reviewed (SEDA-21, 313) (SEDA-24, 354). 

Data on drug pharmacokinetics and drug interactions in patients taking treatment for HIV infection and tuberculosis are scanty, and the current recommendations are almost certain to be modified in the near future. Furthermore, it may be prudent to monitor rifampicin concentrations in the event of intolerance or adverse drug reactions. 

Capone D, Aiello C, Santoro GA, Gentile A, Stanziale P, D Alessandro R, Imperatore P, Basile V. Drug interaction between cyclosporine and two antimicrobial agents, josa-mycin and rifampicin, in organ-transplanted patients. Int J Clin Pharmacol Res 1996 16(2-3) 73-6. 

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