Sulphonylureas Rifampicin

SULPHONYLUREAS RIFAMPICIN 1 hypoglycaemic efficacy Plasma levels of sulphonylureas are J- by induction of CYP-mediated metabolism Watch for and warn patients about symptoms of hyperglycaemia - For signs and symptoms of hypoglycaemia, see Clinical Features of Some Adverse Drug Interactions, Hypoglycaemia... 

Rifampicin is a potent inducer of cytochrome P450 enzymes and thus can diminish the activity of a multitude of other agents such as warfarin, gluco-corticosteroids, cyclosporin, oral contraceptives and sulphonylurea-type oral antidiabetic agents. 

Compounds that may diminish the hypoglycaemic effect and thus cause an increase in the dosage requirement of sulphonylurea include rifampicin (Syvalahti et al., 1974). There is a theoretical risk of a diminished hypoglycaemic effect with corticosteroids and with oral contraceptives. It has been stated that the absorption of glibenclamide from the gastrointestinal tract may be reduced if it is taken together with guar gum. 

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See also in sourсe #XX -- [ ]

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