Richard studies

Most post-approval studies are less than a year in length and involve relatively small numbers of subjects. The Richard study found differences across therapeutic classes in the frequency of FDA requests for post-approval studies and the number of studies requested per drug. 

More information has appeared concerning the nature of the side reactions, such as acetoxylation, which occur when certain methylated aromatic hydrocarbons are treated with mixtures prepared from nitric acid and acetic anhydride. Blackstock, Fischer, Richards, Vaughan and Wright have provided excellent evidence in support of a suggested ( 5.3.5) addition-elimination route towards 3,4-dimethylphenyl acetate in the reaction of o-xylene. Two intermediates were isolated, both of which gave rise to 3,4-dimethylphenyl acetate in aqueous acidic media and when subjected to vapour phase chromatography. One was positively identified, by ultraviolet, infra-red, n.m.r., and mass spectrometric studies, as the compound (l). The other was less stable and less well identified, but could be (ll). 

Compaction Rate Processes The performance of compac tion techniques is controlled by the ability of the particulate phase to uniformly transmit stress and the relationship between apphed stress and the compaction and strength characteristics of the final compacted particulate phase. The general area of study relating compac tion and stress transmission is referred to as powder mechanics (Brown Richards, Principles of Powder Mechanics, Pergamon Press Ltd., Oxford, 1970). 

The 9ai7-quinolizine structure (82) for the labile adduct from 3,5-dimethylpyridine was clearly established by the nuclear magnetic resonance studies of Richards and Higham, and subsequent work showed the labile adduct from 3-methylpyridine was analogous. As the labile adducts from all the pyridines and benzopyridines so far examined have very similar infrared absorption spectra in the 5-7 yn. (carbonyl and aromatic) region and within quite close limits very similar ultraviolet absorption spectra, it can be concluded that all are derivatives of 9aH-quinolizine,... 

When studying heterogeneous equilibria involving clathrates, one is faced with peculiar difficulties owing to the hysteresis effects mentioned in the introduction the solute in a clathrate crystal of hydroquinone, for instance, will not come to thermodynamic equilibrium with the vapor in which it is placed. Consequently it is impossible, or at least very difficult, to measure the equilibrium vapor pressure of the solute in a clathrate by placing some crystals in a tensometer (cf. the experiments of Wynne-Jones and Anderson,58 and those of Leech and Richards reported by Powell33). 

Richards et at. carried out extensive studies on the use of mercury,2 6 277 lead278 279 and silver compounds to terminate anionic polymerization and form polymeric organometallic species which can be used to initiate polymerization. 

Dickinson A. S., Richards D. A semiclassical study of the body-fixed approximation for rotational excitation in atom-molecule collisions, J. Phys. B 10, 323-43 (1977). 

Since both these monomers have been extensively studied, we simulated the experiments by using the same set of parameters for all runs except as noted in the discussions of the Figures. Parameters for all of these runs were obtained from the literature (4., 2r 2., 11, 12, 25, 26). Their values are listed in (Richards, J. R. et al. J. Appl. Poly. Sci., in press). 

See the explanation in Richard Bauckham, The climax of prophecy studies on the Book of Revelation (Edinburgh Clark, 1993), 27 ff. 

The authors wish to gratefully acknowledge the valuable assistance of Mr. Richard Brown in conducting the experiments. Helpful discussions with Dr. Daniel Stone, project officer, and Lt. Col. Michael MacNaughton, project manager, are also acknowledged. This study was supported by funds from the U.S. Air Force Contract No. AF-F08635-78-C-0307. 

O Neill, I. K., Prosser, H. J., Richards, C. P. Wilson, A. D. (1982). NMR spectroscopy of dental materials. I. P studies on phosphate-bonded cement liquids. Journal of Biomedical Materials Research, 16, 39-49. 

The early reaction leading to gelation has been studied by Prosser, Richards Wilson (1982) who used C NMR to examine the interaction between glass G-200 and poly(acrylic acid) solutions, and by Nicholson et... 

Prosser, Richards Wilson (1982) used NMR spectroscopy to study... 

Nirankari, V.S., Varma, S.D., Lakhanpal, V. and Richards, R.D. (1981). Superoxide radical scavenging agents in the treatment of alkali burns an experimental study. Arch. Ophthalmol. 99, 886-893. 

Jacobs, R., Humphrys, J., Dodgson, K.S. and Richards, R.J. (1978). Light and electron microscope studies of the rat digestive tract following prolonged and short-term ingestion of chrysotile asbestos. Br. J. Exp. Path. 59, 443-453. 

Richard Feynman loved to play the bongos. He also loved solving problems. He figured out the reason for the space shuttle Challenger s 1986 explosion by showing that cold weather caused the rubber seals of the booster rocket to fail. Feynman was one of the twentieth century s great theoretical physicists, a Nobel Prize winner who spent much of his career studying atoms. He knew as much about atoms as anyone in the world, and this is what he said about them in his book Six Easy Pieces ... 

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