Superoxide radical scavenger

Nirankari, V.S., Varma, S.D., Lakhanpal, V. and Richards, R.D. (1981). Superoxide radical scavenging agents in the treatment of alkali burns an experimental study. Arch. Ophthalmol. 99, 886-893. 

Selenoureas are prepared by reaction of isoselenocyanates with amines, or by reaction of carbodiimides with a mixture of LiAlH4/Se and by reaction of cyanamides with LiAlH4/Se.267 272 The tyrosinase inhibitory activity and superoxide radical scavenger effect of selenoamides and selenoureas have been investigated (Scheme 84).273 275... 

For phenol 1-37 pM For H2O2 30-130 pM For lecithin 2.0-48.7 mg L"1 Superoxide radical 0.02-2.0 mM <5% Working media ft-hexane for tyrosinase electrode chloroform for catalase electrode chloroform/hexane (50% v/v) containing 1% by volume of methanol for lecithin electrode. Antioxidant capacity of wines was evaluated in terms of polyphenol content, sulfite and ascorbic acid, and compared to superoxide radical scavenging... 

In a study on the antioxidant effects of the components from H. diffusa on xanthine-xanthine oxidase cytochrome c, Lu et al. found that quercetin 3-0-sambubioside (22) and quercetin 3-0-sophoroside (23) are superoxide radical scavengers. The kaempferol glycoside (18) and the itidoid glycosides having cinnamoyl or feruloyl substituents on the glucose units [(31) and (33)], as well as asperuloside (48), were found to be inactive in this assay [29]. 

Blazso, G., Gabor, M., Sibbel, R., and Rohdewald, P., Antiinflammatory and superoxide radical scavenging activities of procyanidins containing extract from the bark oi Pinus pinaster Sol. and its fractions, Pharm. Pharmacol, 3, 217-220,1994. 

In addition to their broncho dilatory action in asthma, P-agonistically active substances of diphe-nolic structure offer radical scavenging properties toward reactive oxygen species as shown in a model system by electron paramagnetic resonance spectroscopy and photometric approaches (Zwicker et al. 1998). The substances under study showed activity in superoxide radical scavenging under aprotic and protic conditions as well. The efficiency of the reaction decreased in the order fenoterol > salbuta-mol > reproterol > terbutaline > oxyfedrine when 5,5-dimethyl-l-pyrroline-N-oxide (DMSO) was used as an aprotic solvent. In an aqueous system, the rate constants decreased in the order fenoterol > reproterol > salbutamol. 

Constantino L., Rastelli, G., Rossi, T., Bertoldi, M. and Albasini, A. 1994, Composition, superoxide radicals scavenging and antilipoperoxidant activity of some edible fruits , Fitoterapia LXV 44—47. 

The antioxidant effects of a polysaccharide (ASP) extracted from Acanthopanax sen-ticosus were evaluated in-vitro by hydroxyl and superoxide radicals scavenging assays, and in-vivo in alloxan-induced diabetic mice. In in-vitro assays, ASP at different concentrations (0.1 -1.6 mg/mL) showed a potent scavenging ability in a concentration-depen-dent manner. Also, in an in-vivo experiment, ASP treatment significantly reduced, in a dose-dependent manner, the levels of lipid peroxidation markers (thiobarbituric acid reactive substances and lipid hydroperoxides) and increased the level of superoxide dismutase (SOD) and catalase (CAT) activities [120]. 

Chun OK, Kim DO, Lee CY (2003) Superoxide radical scavenging activity of the major polyphenols in fresh plums. J Agric Food Chem 51 8067-8072... 

Yasuhisa T, Hideki H, Muneyoshi Y (1993) Superoxide radical scavenging activity of phenolic compounds. IntJ Biochem 25 491-494... 

Inada K, Yokoi I, Kabuto H, Habu H, Mori A, Ogawa N. Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger. Mech Ageing Dev 1996 89 95-102. 

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