Restriction Antigenicity, Receptors

CD4 nonpolymoiphous glycoproteins belonging to immunoglobulin superfamily. Expressed on surface of T helper cells, accessory cells, macrophages and serves as co-receptor in MHC class B-restricted antigen induced T cell activation. Major receptor for IHV-1. 

B lymphocytes (B cells). Bone marrow-derived lymphocytes, expressing an antigen-receptor complex composed of membrane-bound - immunoglobulin (mlg) and associated molecular chains. B cell receptors interact with epitopes directly (no MHC restriction). Activated B lymphocytes produce antibody and are efficient antigen-presenting cells. They are the precursors of plasma cells. 

Stevenson PG, Efstathiou S, Doherty PC, Lehner PJ (2000) Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses. Proc Natl Acad Sci USA 97 8455-8460 Stewart AR, Tollefson AE, Krajcsi P, Yei SP, Wold WS (1995) The adenovirus E3 10.4K and I4.5K proteins, which function to prevent cytolysis by tumor necrosis factor and to down-regulate the epidermal growth factor receptor, are localized in the plasma membrane. J Virol 69 172-181 Straus SE (1984) In Ginsberg HS (ed) Adenovirus infections in humans. Plenum Press, New York and London, pp 451-496... 

NK cells are a subset of lymphocytes found in blood and lymphoid tissues, especially the spleen. They are about 15 an in diameter, possess a kidney-shaped nucleus and have two or three large granules in the cytoplasm. They are derived from the bone marrow. NK cells have the ability to kill certain tumour lines and normal cells infected by virus. Killing by NK cells is not specific for viral antigenic epitopes, and is not restricted by MHC molecules. They do not possess CD3 but do express CD2, CD 16 and CD56, together with a low-affinity receptor for the Fc portion of IgG. 

CD lb Known to be present on thymocytes and dendritic cells CDlc Isoform c also known as non-classical MHC class I-like surface antigen present on thymocytes CD2 Defines T cells involved in antigen non-specific cell activation CD3 Also known as T cell receptor-associated surface glycoprotein on T cells CD4 Defines MHC class Il-restricted T cell subsets... 

CDS Defines MHC class I-restricted T cell subset present on NK cells CDIO Known to be common acute leukaemia antigen CDlla Known to be zn a chain of LFA-1 (leucocyte function antigen-1) present on several types of leucocyte and which mediates adhesion CDllc Known to be z complement receptor 4 a chain. 

A number of both pre-clinical and clinical studies have used the folate receptor or EBP as a target for immunotherapy of ovarian carcinoma [31,32]. Expression of this tumour-associated antigen by normal tissues is restricted [33]. The carcinoma-associated antigen, EGP-2, also called EpCAM, is a 38-kDA transmembrane glycoprotein, present on the majority of simple, stratified and transitional epithelia [34]. The biological function of EGP-2 has not yet been established. 

Lanzavechia, A. (1990). Receptor-mediated antigen uptake and its effect on antigen presentation to class-II restricted T-lymphocytes. Ann. Rev. Immunol., 8, 773-793. 

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