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Restoring Barrier Properties

Reese TS, Karnovsky MJ. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 1967 34 207-217. [Pg.34]

Shakib M, Cunha-Vaz JG. Studies on the permeability of the blood-retinal barrier. IV. Junctional complexes of the retinal vessels and their role in the permeability of the blood-retinal barrier. Exp Eye Res 1966 5 229-234. [Pg.34]

Demeuse P, Kerkhofs A, Struys-Ponsar C, Knoops B, Remade C, van den Bosch de Aguilar P. Compartmentalized coculture of rat brain endothelial cells and astrocytes a syngenic model to study the blood-brain barrier. J Neurosci Methods 2002 121 21-31. [Pg.35]

Duport S, Robert F, Muller D, Grau G, Parisi L, Stoppini L. An in vitro blood-brain barrier model cocultures between endothelial cells and organotypic brain slice cultures. Proc Natl Acad Sci USA 1998 95 1840-1845. [Pg.35]

In an own study we tested topical corticosteroids in combination with 5% lanolic acid.68 An improvement of barrier function could be detected. Formulations containing co-3 and co-6 fatty acids may help in the restoration of barrier properties. Higher efficacy of these products may be achieved by combining different classes of stratum corneum lipids 68 Escobar et al.64 showed a clinical improvement of scaling and plaque thickness for topical fish oil compared to the base-treated site in a four week treatment64... [Pg.139]

Lanolin has stood the test of time as an emulsifier and skin emollient. Its complex nature has been a rich resource of derivatives formed from fractionation and chemical reactions. Although the composition of lanolin is different from the lipids found on the surface of human skin, lanolin has been demonstrated to be equivalent in its ability to restore barrier function. In addition to the beneficial effects attributable to its physical properties, lanolin may also have a pharmacological effect on the epidermis. [Pg.314]

The restorative properties of high-glycerin therapeutic moisturizers are hypothesized to be related to a glycerol reservoir within the SC. This provides a mechanism for enhancing barrier characteristics... [Pg.233]

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