Respiratory tract, neoplasms

Wada, S., Y. Nishimoto, M. Miyanshi, S. Katsuta, M. Nishiki, A. Yamada, S. Tokuoka, H. Umisa, and M. Nagal, 1962b. MaUgnant respiratory tract neoplasms related to poison gas exposure. Hiroshima J. Med. Sci. 11 81-91. 

The most common adverse effect with omalizumab is injection-site reaction, reported in 45% of patients in clinical trials. Other adverse effects include viral and upper respiratory tract infections, sinusitis, headache, and pharyngitis. Rare cases of malignant neoplasms and anaphylaxis were reported during clinical trials of omalizumab in asthma. Patients should be monitored for at least 2 hours following the injection so that anaphylaxis and/or injection-site reactions may be managed.25... 

Chronic inhalation exposure of rodents to 1,2-dibromoethane has been associated with neoplasms in the respiratory tract, as well as in other organ systems. Two studies have examined the carcinogenic potential of 1,2-dibromoethane in rodents after inhalation exposure (NTP 1982 Wong et al. 1982). There was also an A strain mouse assay (Adkins et al. 1986). 

Rhabdomyosarcomas developed in rats injected intramuscularly with the powder of either pure cobalt metal or cobalt oxide. In other studies implantation of cobalt caused local fibrosarcomas in rabbits, but inhalation studies in hamsters did not reveal any increase in tumors from cobalt oxide. Lifetime exposure to cobalt sulfate by inhalation resulted in increased incidence of alveolar/bronchiolar neoplasms and a spectrum of inflammatory, flbrotic, and proliferative lesions in the respiratory tract of male and female rats and mice. ... 

Male and female mice exposed at concentrations up to 4mg/m 6 hours/day for 104 weeks had clear evidence of carcinogenicity based on increased incidences of alveolar/bron-chiolar neoplasms. In rats similarly exposed at concentrations up to 2 mg/m there was some evidence of carcinogenicity in male rats and equivocal evidence in females based on the occurrence of alveolar/bronchiolar neoplasms. Exposure to vanadium pentoxide also caused a spectrum of nonneoplastic lesions in the respiratory tract including alveolar and bronchiolar epithelial hyperplasia, inflammation, fibrosis, and alveolar histocytosis of the lung. Elyper-plasia of the bronchial lymph node occurred in female mice, and an unusual squamous metaplasia of the lung occurred in rats. ... 

Respiratory Tract. While neoplasms of the same cell of origin in the larynx, trachea, and major bronchi would usually be combined, neoplasms of the peripheral lung (bronchiolar-alveolar neoplasms) would be analyzed separately. Similarly, neoplasms of the nasal cavity would not normally be combined with those found in the rest of the respiratory tract. 

---