Respiratory tract, neoplasms of

ACS Symposium Series American Chemical Society Washington, DC, 1980. 

Additionally, in vitro tests should not elimate animal testing but may help in tests with animals. The proper use of several in vitro test systems will greatly aid our understanding of which metal compounds are hazardous. These screening tests may also allow us to identify carcinogens in air samples from the industrial environment. 

Metals Induce Cancer When Administered to Experimental Animals. Again, the reader is referred to many recent comprehensive reviews which discuss the evidence that certain metals cause cancer in experimental animals (9,10,J1). The most credible data implicates cadmium, chromium, co 6 a TT, and nickel as carcinogens in experimental animals. It should be noted that while arsenic has been shown to be responsible for the induction of human cancer, attempts to induce cancer in experimental animals with arsenic and its compounds have not been successful. In contrast, while cobalt induced cancer in experimental animals, numerous epidemiological studies have failed to show a correlation between excessive human exposure to cobalt and the induction of human neoplasia. One of the most studied metal carcinogens are the nickel compounds, of which crystalline Ni3 2 appears to be the most potent (1,2,12). Ni3 2 has been shown to induce cancer at 

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