Renal failure Reproduction

Toxicology LD50 (oral, rat) > 5000 mg/kg, (skin, rat) > 5 g/kg, (IP, rat) > 1 g/kg, (subcut., rat) > 1 g/kg LC50 (inh., rat) > 94,500 pg/m may cause normocytic anemia, bone marrow and spleen changes, changes in kidney or liver wt., renal failure reproductive effector Uses Herbicide for control of grass weed Trade Name Synonyms Hinochloa t[Bayer CropScience AG... 

SAFETY PROFILE Moderately toxic by ingestion and intravenous routes. Human systemic effects by intravenous route blood, changes in tubules (including acute renal failure, acute tubular necrosis). An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. 

Elevated production of Vg in males or immature fish may be associated with two different types of consequences for an individual decreased survival or impaired reproduction. First, extremely high levels of Vg in the circulation of males (tens of mg/ml) may cause renal failure and therefore pose a threat to survival, as has been demonstrated in summer flounder, Paralichthys dentatus44. Second, high levels of Vg in males or juveniles may be produced in response to an EDC exposure that also alters sexual development and causes impaired fertility. In the first case, Vg overproduction causes an overt toxicity problem in the second, it serves as an indicator of a more subtle reproductive problem. The association between elevated plasma Vg and other... 

Control of the various phases of the growth cyde is exerted by the cyclical activation and repression of the cyclin-dependent kinases. Two important regulators of the cell cycle have been now shown to participate in acute renal failure. One family of proteins, the cycUn-dependent kinase inhibitors, which bind to and inhibit assembled cyclin kinases, and in particular the cycUn-dependent kinase inhibitor protein p21 is expressed in all forms of renal failure studied, induding ischemia-reperfusion, cisplatin and obstructive uropathy. This protein binds to and inhibits the CDKs that regulate the Gl/S a G2/M transition. P21 expression is enhanced by hostile environmental conditions [82]. The function of these checkpoints is to monitor the fidelity of DNA rephcation and other macromolecular components of the cell necessary for accurate reproduction... 

Toxicology LD50 (oral, rat) 11,900 mg/kg, (IV, mouse) 518 mg/kg mod. toxic by ing., IV routes human blood systemic effects by IV route extremely high repeated doses may cause nausea, diarrhea, Gl disturbances, flatus acute renal failure and tubular necrosis experimental teratogen, reproductive effects mutagenic data TSCA listed Precaution Combustible liq. 

Those which are produced by fungal microbes are linked directly to animal and human health as being the products of fungal growth. These mycotoxins are causative agents of gastrointestinal disturbances, cancer, reproductive failure, renal and nervous diseases, and abnormal tissue perfusion. 

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