Remeron

Mirtazapine Remeron Yes Tablet, disintegrating tablet (SolTab) 15 15-45 Once daily... 

Mirtazapine Remeron o2 antagonist, 5-FIT2 5-FIT3 antagonist... 

Mirtazapine (Remeron) is a newer antidepressant that also blocks 5-HT reuptake, but additionally has antagonistic effects at adrenergic o2, 5-HT2, and 5-HT3 receptors (Stahl 1998). Mirtazapine appears to have indirect agonistic effects on 5-HTlA receptors, which may contribute to its antidepressant effect (Berendsen and Broekkamp 1997). Nefazodone, as well, has SSRI and 5-HT2 antagonist effects. The 5-HT2 antagonist effects of these antidepressants is believed to be responsible for their lower incidence of sexual side effects (Nutt 1997). 

Atypical Antidepressants. The atypical antidepressants are not a true class in the same sense as SSRIs or TCAs. There is no unifying property to these antidepressants. Each of these antidepressants is actually a class unto itself that is structurally and functionally different from all other antidepressants. The atypical antidepressants include trazodone (Desyrel), bupropion (Wellbutrin), venlafaxine (Effexor), duloxetine (Cymbalta), nefazodone (Serzone), and mirtazapine (Remeron). 

Mirtazapine (Remeron). Mirtazapine is the newest of the atypical antidepressants. It mainly works by blocking the alpha-2 negative feedback receptor and thus increases norepinephrine and serotonin activity. In addition, mirtazapine blocks serotonin-2 and serotonin-3 receptors to produce a specific serotonin action like nefazodone. Mirtazapine is approved for the treatment of depression. Its use in the anxiety disorders is being studied. 

Care should be taken when prescribing other medications with clozapine. The mood stabilizer carbamazepine (Tegretol) and perhaps the antidepressant mirtazap-ine (Remeron) should not be taken with clozapine because they might further increase the risk of agranulocytosis. Likewise, the antidepressant bupropion (Wellbutrin, Zyban) should not be taken with clozapine because it may add to the seizure risk. 

A controlled trial of duloxetine (Cymbalta)—like venlafaxine a dual serotonin-norepinephrine reuptake inhibitor—in the treatment of GAD is currently underway. Anecdotal data suggests that nefazodone (Serzone) and mirtazapine (Remeron) may be effective in the treatment of GAD, though no controlled data is available. In addition, recent concerns regarding nefazodone and liver toxicity have limited this medication s utility. Please refer to Chapter 3 for more information regarding these antidepressants. 

Antidepressants. The most widely used psychiatric medicines with the broadest range of application in TBI patients are undoubtedly the SSRI antidepressants. They are well tolerated, unlikely to worsen any of the preexisting deficits associated with TBI, and offer relief from not only depression but also impulsivity and virtually all variants of anxiety in these patients. As such, SSRIs are the preferred first-line treatment for all anxiety disorders after TBI. Other newer antidepressants that also work (at least in part) by boosting serotonin activity, namely, mirtazapine (Remeron), nefazodone (Serzone), venlafaxine (Effexor XR), and duloxetine (Cymbalta) can also be considered, but they have not been well studied in patients with TBI. In... 

Blocking the norepinephrine alpha-2 receptor can also increase norepinephrine activity. The alpha-2 receptor provides feedback to the neurons to stop releasing norepinephrine and, for that matter, serotonin. By blocking the alpha-2 receptor, norepinephrine and serotonin are more readily released. The atypical antidepressant mirtazapine (Remeron) acts in part in this manner (see Table 13.2). 

Tablets, orally disintegrating 15, 30, and 45 mg Rx) Remeron SoiTab (Organon)...

Ruvoxamine (Luvox) Imipramine (Tofranil) Mirtazapine (Remeron, RemCTon SolTab) Nefazodone (Serzone) Nortriptyline (Aventyl, Pamelor)... 

Mirtazapine (Remeron) enhances both serotonergic and noradrenergic neurotransmission. By blocking presynaptic aj-adrenoceptors, mirtazapine causes release of norepinephrine. Indirectly, through noradrenergic modulation of serotonin systems, mirtazapine also causes increased release of serotonin. It is an antagonist... 

Rachel was between a rock and a hard place. Like many others, she had become dependent on medications whose effectiveness is uncertain but whose side effects are often certainly bad. After so many years, she had lost sight of the person she might be without medications, and she had surrendered to a life bounded by them. Her newest medication, Remeron, captured her dilemma. The drug knocked her out at night, ensuring sleep, but caused her to walk into many more walls than I used to each morn-... 

Norepinephrine-serotonin modulators Mirtazapine Remeron 15 15 5 7.5, 15, 30, 45, soltab 20... 

AccessMedicine Print Chapter 30. Antidepressant Agents Oral 25, 50, 75 mg tablets Maprotiline (generic, Remeron)... 

Mirtazapine [Remeron] Exact mechanism unclear may increase norepinephrine and serotonin activity by blocking inhibitory presynaptic autoreceptors Low incidence of sedative, anticholinergic, and cardiovascular side effects May cause agitation, anxiety, other mood changes... 

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