Serotonin action

WS Marshall, SD Klyce. (1984). Cellular mode of serotonin action on Cl transport in the rabbit corneal epithelium. Biochim Biophys Acta 778 139-143. 

Mirtazapine (Remeron). Mirtazapine is the newest of the atypical antidepressants. It mainly works by blocking the alpha-2 negative feedback receptor and thus increases norepinephrine and serotonin activity. In addition, mirtazapine blocks serotonin-2 and serotonin-3 receptors to produce a specific serotonin action like nefazodone. Mirtazapine is approved for the treatment of depression. Its use in the anxiety disorders is being studied. 

The second theory is that some atypicals work by balancing dopamine blockade with serotonin receptor blockade. We know that one of the roles of serotonin is to attenuate (or lessen) dopamine activity. Blocking serotonin action therefore may release just enough dopamine activity in the nigrostriatal pathway to avoid EPS without interfering with the antipsychotic effects in the mesolimbic area. 

FIGURE 7—49. Heroic combo 5 Venlafaxine plus nefazodone. Serotonin will be double-boosted to a certain extent by nefazodone alone. At any dose of venlafaxine, the boosting of serotonin will be considerably enhanced. This enhancement of nefazodone s serotonin action can also be replicated by SSRIs, but citalopram may be the best tolerated. At high doses of venlafaxine, there will be not only boosting of 5HT but also single-boosting of NE and maybe DA. 

DMA on vascular strips (associated with serotonin action) were not impressive in comparison with structurally related psychedelics, and... 

Decloxlzlne (UCB-1402) (X), in addition to the antihlstaminlc and anti-serotonin actions expected as a result of its structure, has been reported to possess a direct-acting muscolotroplc bronchodllator action equivalent to that of isoproterenol. ... 

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