Reichstein substance 21-acetate

Names synonyms CHLOROPREDNISONE ACETATE 6a-chloropredni one acetate 6a cbloro A -pregnadien-17. 21 diol 3.11,20-trione 21-acetate. CORTICOSTERONE 11,21 dibydroxyprogesterone A -pregnene I I fi,21 -diol-3,20-dionc 11. 2 J dihydroxy-4 pregncne-3.20-dione Kendall compound B Reichstein substance H. CORTISONE 1 hydroxy-11 -dehydrocorticosterone 17a,21 -dihydroxy-4-pregnene 3,l 1.20 trione A -pregnene-17a,21 -diol 3.11.20>trione Kendall compound E Wintersteiner compound F. 

Names synonyms FLURANDRENOLONE 6 fluoro i 6s hyd roxyhyd rocori isone 16.17-acelonidc 6a-fluoro 11, 21 -dehydroxy-16s. 17 s-isopropylidenedioxy-pregna-4-ene 3, 20-dione. HYDROCORTISONE cortisol 17-hydroxycorticosterone hydrocortisone free alcohol l 0, 7s.21 trihydroxy-4-pregnene-3.20-dione 4-pregnene-11 17a, 21 lriol-3.20-dione Kendall compound F Reichstein substance M. HYDROCORTISONE ACETATE cortisol acetate hydrocort isone-21 -acetate 17-hydroxycorticosterone-21 -acetate. 

It grew out of another discovery in the senior author s laboratory, namely, that Reichstein s compound S could be converted in high yield into 11-epicortisol (1) by the enzymes of fungi of the genus Aspergillus The conversion of this inactive substance into the hormone cortisol thus became a problem of considerable importance. A route involving the 9,11-dehydro steroid (3) readily prepared from 11-epicortisol via its 21-acetate 11-tosylate... 

A -cortisol prednisolone, cortisone (ban. inn] (cortisone acetate [usan] Kendall s compound E Reichstein s Substance Fa Wintersteiner s compound F NSC 9703 Cortisyl ) is a natural adrenal cortical hormone, a CORTICOSTEROID, which is converted to hydrocortisone in the liver. It has both GLUCOCORTICOID and MINERALOCORTICOID activity. It can therefore be used orally to make up for hormonal deficiency (especially mineral balance), for instance, following surgical removal of the adrenal glands. It can also be used for its ANTIINFLAMMATORY and ANTIALLERGIC properties in treating rheumatoid arthritis and in rheumatic fever therapy, cortisone acetate cortisone. 

Trihydroxy-5a-pregnan-20-one 30,11(1,21 -triliydroxy-20-oxo-5o-pregnane Reichstein s substance R. Cj,Hw04 mol wt 350.48. C 71.96%. H 9.78%. O 18.26%. Isolation from adrenal glands Reichstein, von Euw, l civ Chim. Acta 21, 1197 (1938) Reichstein. ibid. 1490. Partial synthesis by hydrogenation of corticosterone acetate Pataki Cl of., J. 

Cortexone, Reichstein s substance Q, Il-deoxy-corticosterone, DOC, 21-hydroxypregn-4-ene-3,20-dlone a mineralocorticoid from the adrenal cortex. The acetate or glucoside is used in the treatment of Addison s disease, and of shock. For structure and biosynthesis, see Adrenal corticosteroids. 

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