Corticosterone 11-deoxy

Drugs belonging to this class are glucocorticoids (hydrocortisone, 11-dehydrocorti-costerone, corticosterone), mineralocorticoids (aldeosterone, 11-deoxycorticosterone, ll-deoxy-17-oxycorticosterone), and sex hormons (androsterone, androstendion, estrone, progesterone). 

For the synthesis14 of 11-deoxy-corticosterone acetate, a convenient starting material was the readily available alcohol 39. On photolysis under oxygen, the corresponding nitrite gave the desired nitrate 40. Standard oxidation, hydrolysis and Oppenauer oxidation gave 18-nitrate 41 which was readily reduced under mild conditions with zinc dust to give the 18-... 

Metyrapone inhibits the enzyme, steroid 1113-hydroxylase, that converts 11-deoxy precursors into hydrocortisone, corticosterone and aldosterone. It affects synthesis of aldosterone less than that of glucocorticoids. 

Polymerization of cis- or trans-pentadienes as inclusion compounds with deoxycholic acid, by y-irradiation, gave optically active polymers.The electrochemical determination of vitamin D in the presence of vitamin A has been explored. Substantial losses of corticosterone and its 11-deoxy-derivative occurred when methanolic solutions were evaporated in soda-lime test tubes, although borosilicate tubes were satisfactory. The fire and explosion hazards have been assessed for a variety of commercial steroids in aerosol form. A review of... 

Deficiency in the 18-oxidation of corticosterone was first described by Visser and Cost (V8) in three related infants with salt-losing syndrome. A defect in the conversion of corticosterone to aldosterone is not associated with adrenal hyperplasia since cortisol production is not affected and no excess corticotropin is produced. The patients studied by Visser and Cost (V8) had low serum sodium concentrations with high serum potassium. The total excretion of 17-OS and cortisol metabolites was normal. However, no aldosterone was detected in the urine and abnormally large amounts of 17-deoxy Czi steroids were excreted (corticosterone, 11-dehydrocorticosterone, tetrahydrocorticosterone, allotetrahy-drocorticosterone, and tetrahydro-ll-dehydrocorticosterone). Ulick and co-workers (Ul) have also studied an infant with the salt-losing syndrome associated with defective production of aldosterone. These workers found increased production of corticosterone, 18-OH-corticosterone and... 

The glucocorticoids mainly influence carbohydrate metabolism and, to a certain extent, protein and lipid metabolism (see Table 14 and Figure 55). The main glucocorticoid is cortisol, with a daily secretion of 15 mg. Cortisol is synthesized through the 11-beta-hydroxylation of 11-deoxy-cortisol. Besides cortisol, the adrenal gland also synthesizes and releases a small amount of corticosterone, whose synthesis from 11-deoxycorticosterone is catalyzed by 11-beta-hydroxylase. A deficiency of 11-beta-hydroxylase causes ... 

Figure 12 Screening of a steroid library, (a) An imprinted polymer prepared for lla-hydro-xyprogesterone. Mobile phase dichloromethane (DCM) - 0.1% acetic acid v/v, Flux 0.5mL/min. (b) An imprinted polymer prepared for lla-hydroxyprogesterone. Gradient elution, 0-25 min, DCM 0.1% acetic acid v/v 25-30 min, DCM 0.1-5% acetic acid v/v 30-40 min, DCM 5% acetic acid v/v 40-45 min, DCM 5-0.1% acetic acid v/v. Flux 0.5mL/min. (c) A control polymer prepared in the absence of template molecule. Isocratic elution, DCM 0.1% acetic acid v/v. Flux 0.5mL/min. Sample component. (1) lla-hydroxyprogesterone, (2) lla-hydroxyprogesterone, (3) 17a-hydroxyprogesterone, (4) progesterone, (5) 4-androsten-3,17-dione, (6) l,4-androstadiene-3,17-dione, (7) corticosterone, (8) cortexone, (9) 11-deoxy-cortisol, (10) cortisone, (11) cortisone-21-acetate, (12) cortisol-21-acetate. Reproduced from Ref. 58, with permission.

T sex hormones, mascullnisatlon, hypertension because W-deoxy corticosterone has mlneralocorticold properties... 

Cortexone, Reichstein s substance Q, Il-deoxy-corticosterone, DOC, 21-hydroxypregn-4-ene-3,20-dlone a mineralocorticoid from the adrenal cortex. The acetate or glucoside is used in the treatment of Addison s disease, and of shock. For structure and biosynthesis, see Adrenal corticosteroids. 

Determination of 18-Hydroxy-ll-deoxy-corticosterone in Adrenal Venous Blood by Gas Chromatography Cas. Lek. Cesk. 114(42) 1308-1311 (1975) CA 85 1975p... 

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