Kendall’s compound

Into each of 27 Erlenmeyer flasks are placed 150 mg of Kendall s Compound F (hydrocortisone). The flasks and contents are then sterilized for 15 minutes at 15 pounds steam pressure (120 C). To each flask are then added 5.0 ml of ethanol. The 24-hour bacterial culture is then transferred asepticaliy and the resulting suspensions are Shaken on a shake table at 220 rpm and 28°C for 48 hours. The pH at the end of the shake period is 7.0. 

Kendall s compound E Wintersteiner s compound F Reichstein s substance Fa 11-Dehydrocortisol... 

During the 1930 s, several seientists isolated eortisone among other adrenoeortieal hormones from the suprarenal glands of cattle. Kendall et al. [12-14] isolated 8 steroidal hormones (cortisone being Kendall s compound E), while Wintersteiner et al. [15,16] isolated 4 compounds (Wintersteiner s compound F was cortisone). Reichstein [17] isolated 31 substances, with his compound Fa being cortisone. Kuizenga and Cartland [ 18] isolated 5 substances, and Wettstein et al. [ 19] isolated 18 hormones. 

A -cortisol prednisolone, cortisone (ban. inn] (cortisone acetate [usan] Kendall s compound E Reichstein s Substance Fa Wintersteiner s compound F NSC 9703 Cortisyl ) is a natural adrenal cortical hormone, a CORTICOSTEROID, which is converted to hydrocortisone in the liver. It has both GLUCOCORTICOID and MINERALOCORTICOID activity. It can therefore be used orally to make up for hormonal deficiency (especially mineral balance), for instance, following surgical removal of the adrenal glands. It can also be used for its ANTIINFLAMMATORY and ANTIALLERGIC properties in treating rheumatoid arthritis and in rheumatic fever therapy, cortisone acetate cortisone. 

In addition, 5 has the -OH at the 4-position and a methyl group at the 1-position of the A-ring. Kendall s compound has more structural similarity to strigol than 3, yet its activity is only about 22 that of strigol for witchweed germination. 

AlIopregnane-30,21-dioI-U,2O-diane. 30,2i-Dh hydroxy-5a-pregnaitem11,20-dione 30,21 -dihydroxy-11,20-dioxo-5a-pregnane Kendall s compound H Reich stein s... 

Kendall s compound B Corticosterone 1 l/S,21-Dihydroxy-A -pregnene-3,20-dione... 

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