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Regulation of cellular growth

Shermilamines B (37) and C (38) (and also diplamine 46) showed dose-dependent inhibition of proliferation in HCT cells in vitro and inhibited the topoisomerase (TOPO) II-mediated decatenation of kinetoplast DNA (kDNA) in a dose-dependent manner [41]. These results suggest a possible cytotoxicity mechanism for these compounds. Furthermore, shermilamine B also displayed cytotoxicity against KB cells [43] and was reported as a potent regulator of cellular growth and differentiation, affecting cAMP-mediated processes [44]. [Pg.820]

Saier, M.H. Jr., Daniels, G.A., Boemer, P., Lin, J. (1988). Neutral amino acid transport systems in animal cells. Potential targets of oncogene action and regulators of cellular growth. J. Membr. Biol. 104,1-20. [Pg.121]

At the moment, the role of p53 and its related genes in the regulation of cell growth signaling by carotenoids is not well understood and the results appear controversial. It is possible that several factors may influence the modulatory effects of P-carotene and other carotenoids on p53 levels, including the concomitant presence of smoke, the type and the concentration of the carotenoid, the association with other antioxidants as well as the biological cellular environment. [Pg.471]

The thyroid and parathyroid glands serve a number of vital endocrine functions. The thyroid gland synthesizes and secretes the thyroid hormones T3 and T4. These hormones are important regulators of cellular metabolism and metabolic rate. Thyroid hormones also interact with other hormones to facilitate normal growth and development. The parathyroid glands control calcium homeostasis through the release of PTH. This hormone is crucial... [Pg.472]

ATP has a ubiquitous and dominant role in cellular metabolism. This role can be appreciated more fully if cognizance is extended to the energy requirements of cells, to the regulation of cellular activity and metabolism imposed by ATP, and to what interference with ATP production means to the growth of a chloro-phyllous plant. Plants store oxidative and photochemical energy in the terminal phosphate bonds of ATP. The terminal bond energy is used subsequently to perform the chemical, mechanical, and osmotic work of the cell. [Pg.76]

See other pages where Regulation of cellular growth is mentioned: [Pg.432]    [Pg.179]    [Pg.287]    [Pg.40]    [Pg.259]    [Pg.208]    [Pg.183]    [Pg.242]    [Pg.87]    [Pg.1278]    [Pg.115]    [Pg.1861]    [Pg.276]    [Pg.256]    [Pg.6]    [Pg.432]    [Pg.179]    [Pg.287]    [Pg.40]    [Pg.259]    [Pg.208]    [Pg.183]    [Pg.242]    [Pg.87]    [Pg.1278]    [Pg.115]    [Pg.1861]    [Pg.276]    [Pg.256]    [Pg.6]    [Pg.262]    [Pg.710]    [Pg.482]    [Pg.11]    [Pg.427]    [Pg.302]    [Pg.338]    [Pg.4]    [Pg.454]    [Pg.442]    [Pg.220]    [Pg.206]    [Pg.486]    [Pg.368]    [Pg.402]    [Pg.1269]    [Pg.346]    [Pg.29]    [Pg.440]    [Pg.227]    [Pg.247]    [Pg.119]    [Pg.211]    [Pg.256]    [Pg.57]    [Pg.189]    [Pg.49]    [Pg.166]    [Pg.176]    [Pg.341]   
See also in sourсe #XX -- [ Pg.242 ]



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