Regulation case studies

Construction Industry Research and Information Association (1997) CDM Regulations - case study guidance for designers an interim report. Report 145. UK CIRIA. 

Because of the toxicity of CE, the aqueous effluent from the ethyl chloride reactor, Ri, causes significant problems for the bio-treatment facility. The objective of this case study is to optimally intercept CE-laden streams so as to reduce the CE content of R] to meet the following regulations ... 

The intention of the risk-based approach introduced by the FDA in 2002 was to modernize the FDA s regulation of the pharmaceutical quality of drugs. This was followed by the EMEAs regulation in recognition of such an important topic. This case study summarizes the progress to date for both the FDA and EMEA in the implementation of the risk-based approach. 

The primary object of this book is to provide the HPLC practitioner with a handy guide to the use of HPLC for analyzing pharmaceutical compounds of interest. This means familiarizing the practitioner with the theory, instrumentation, regulations, and numerous applications of HPLC. This handbook provides practical guidelines using case studies on sample preparation, column or instrument selection, and summaries of best practices in method development and validation, as well as tricks... 

Many aspects of substitution, its conditions and effects already described in existing subject literature were confirmed in the course of work on the case studies, but this was mostly only in certain cases and without any systematic framework for interpretation. This includes the enforcement deficit for application-related regulations in small and medium-sized enterprises, the obstractive behaviour of powerful associations or the trend towards more public attention with regard to substances in consumer products - in comparison with commercially used preparations or substances. 

The interaction of regulative driving forces (regulative push and pull) as well as the importance of the (limited) official execution can be substantiated well using the case studies ... 

The announcement of new regulations or initiatives for enforcement. A market opportunity is created for innovative products and services when the users of hazardous substances expect new regulations or the monitoring authorities initiate new checks. The SubChem case studies demonstrated that a clearly perceived initiative is frequently more effective than an attempt at the saturation monitoring of regulations. 

Caldwell, D.J. 1999. Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk A case study using alkyl phthalates. Regul. Toxicol. Pharmacol. 30 45-53. 

Autointoxication, in which an organism releases a toxic chemical that suppresses its own growth, is one phase of allelopathy. Autointoxication can also be important in intraspecific interactions, such as the regulation of population size by self-thinning. Several case studies conducted in Taiwan are described below. 

The sympathetic nervous system is an important regulator of virtually all organ systems. This is particularly evident in the regulation of blood pressure. As illustrated in the case study, the autonomic nervous system is crucial for the maintenance of blood pressure even under relatively minor situations of stress (eg, the gravitational stress of standing). 

Case Studies on Chemical Flue Gas Treatment as a Means of Meeting Particulate Emission Regulations... 

Case study 1 - pest and pathogen regulation in organic versus conventional cereal crops in Europe... 

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