Registry facility

The structure entry operation has just recently been completed, having taken considerably less time than originally anticipated. Now that the high volume input of the database "backlog" is done, it is planned that routine dally update of the database with low volume "current" structures will be handled by the online registry facility which is nearing completion and which will be discussed later. 

The compound registry and search system provides the graphical usei Interface, Interactive command language, search functions, and database management support which allow compound-associated Information to be added to the database and existing data to be modified or queried. The registry facility Is available on a restricted basis to those users with authority to update the compound database. On the other hand, the query facility is available to all users and allows search, display, and hard copy output of the various types of Information stored In the database. 

The world wide facilities for retrieving chemical information provided by the Chemical Abstract Service (CAS on-line) have made it a relatively easy matter to obtain CAS registry numbers of substances, and most of the numbers in this monograph were obtained via CAS on-line. We should point out that two other available useful files are CSCHEM and CSCORP which provide, respectively, information on chemicals (and chemical products) and addresses and telephone numbers of the main branch offices of chemical suppliers. 

The Comprehensive Environmental Response, Compensation, and Liability Aet (CERCLA) [42 U.S.C. 9601 et seq ], as amended by the Superflind Amendments and Reauthorization Aet (SARA) [Pub. L. 99-499], requires that the Agency for Toxic Substances and Disease Registry (ATSDR) develop jointly with the US. Enviromnental Protection Agency (EPA), in order of priority, a list of hazardous substances most commonly found at facilities on the CERCLA National Priorities List (NPL) prepare toxicological profiles for each substance included on the priority list of hazardous substances and assure the initiation of a research program to fill identified data needs associated with the substances. 

The toxicological profiles are developed in response to the Superfund Amendments and Reauthorization Act (SARA) of 1986 (Public Law 99-499) which amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund). Section 211 of SARA also amended Title 10 of the U. S. Code, creating the Defense Environmental Restoration Program. Section 2704(a) of Title 10 of the U. S. Code directs the Secretary of Defense to notify the Secretary of Health and Human Services of not less than 25 of the most commonly found unregulated hazardous substances at defense facilities. Section 2704(b) of Title 10 of the U. S. Code directs the Administrator of the Agency for Toxic Substances and Disease Registry (ATSDR) to prepare a toxicological profile for each substance on the list provided by the Secretary of Defense under subsection (b). 

CLAB underground spent fuel disposal facility, 17 549 Cladinose, 4 713 Claflin refiner, 15 105 CLAIMS-Citation database, 15 238 CLAIMS-Citation files, 15 247, 248 CLAIMS Compound Registry, 15 247 CLAIMS databases, 15 237, 247 Claisen condensation, 10 505 Claisen-Cope rearrangement, 24 479,... 

Prior to 9/11, an assessment of chemical plant site security by the Agency for Toxic Substances and Disease Registry (ATSDR) was considered by many to be the most comprehensive analysis that was publicly available. ATSDR researchers reviewed national statistics on domestic terrorism compiled by the FBI in 1995 and interviewed security staff from facilities and potential targets in one community with numerous chemical plants. Reviewers found the following concerns ... 

Obstacles remained as PTCA was not universally available and often associated with considerable time delay, especially in off peak hours. In the National Registry of Myocardial Infarction-2 (NRMI-2 >27,000 patients), total ischemia time (symptom onset to balloon inflation) was 3.9 h with onset to hospital arrival 1.6 h [45]. Unadjusted in-hospital mortality was higher in patients treated later. Door to balloon time > 2 h was related to in-hospital death (41-62% adjusted odds increase) and centers who treat >3 STEMIs/month had improved in-hospital mortality compared to less experienced facilities (Figs. 5.4 and 5.5). Lastly, similar to trials of unstable angina, PTCA was plagued by high restenosis rates... 

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