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Regenerative nodules

Sinusoidal damage from cirrhosis is the most common cause of portal hypertension. The sinusoids are porous vessels within the liver that surround radiating rows of hepatocytes, the basic functional cells of the liver (Fig. 19-2). Progressive destruction of hepatocytes and an increase in fibroblasts and connective tissue surrounding the hepatocytes culminate in cirrhosis. Fibrosis and regenerative nodules of scar tissue... [Pg.324]

Cirrhosis Widespread disruption of normal liver structure by fibrosis and the formation of regenerative nodules that is caused by any of various chronic progressive conditions affecting the liver. [Pg.1562]

Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury. It is an advanced stage of liver fibrosis that is accompanied by distortion of the hepatic vasculature. [Pg.346]

Hepatic copper > 250 p g dry weight Due to regional variation - In pts with active Uver disease - In pts with regenerative nodules Cholestatic syndromes... [Pg.468]

The liver is usualy not enlarged or pa taMe, and it may become smaller and fibrotic. True cirrhosis (i.e., the destruction of normai hepatic architecture by fibrous sepia tiiat encompasses the regenerative nodules of hepatocytes) is rare in domestic animals with chronic hepatotoxicosis. Most chronic liver failure tram acute or chronic bndcosis in animals is characterized by marked fibrosis, but does not involve regenerative trodules. [Pg.100]

Hepatocellular nodules maybe neoplastic or non-neoplastic. The latter usually correspond to a regenerative response to injury. The size and structure of regenerative nodules varies with the distribution and severity of the hepatic injury, leading to a complex classification. Biliary and stromal cells also produce neoplastic or regenerative lesions (Yeung et al. 2003). [Pg.76]

Hepatocellular carcinoma is one of the most common malignant neoplasm world-wide, with an estimated incidence of more than 500,000 new cases per year (Llovet et al. 2003). Hepatocellular carcinoma usually occurs in patients with long standing cirrhosis induced by hepatitis B or C viral infections or protracted alcohol intake. In drrhotic liver, hepatocellular carcinoma is the result of the evolution of regenerative nodules into dysplastic nodules, with different degree of atypia, and finally into overt hepatocellular carcinoma (Arakawa et al. 1986). However,... [Pg.209]

Cirrhosis The accumulation of fibrosis in the liver defined by the presence of bridging fibrosis and regenerative nodules. [Pg.1609]


See other pages where Regenerative nodules is mentioned: [Pg.695]    [Pg.97]    [Pg.566]    [Pg.858]    [Pg.19]    [Pg.24]    [Pg.397]    [Pg.400]    [Pg.400]    [Pg.401]    [Pg.80]    [Pg.80]    [Pg.82]    [Pg.84]    [Pg.171]    [Pg.1601]   


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