Redox modulation

In summary, the apparent redox modulation of lycopene certainly affects two important redox sensitive transcription factors at higher concentrations of lycopene. However, electrophilic lycopene oxidation products cannot be ruled out as the major activators and the activation may be due to specific molecular interactions. 

Calabrese Y, Colombrita C, Sultana R, Scapagnini G, Calvani M, Butterfield DA, Stella AM. 2006c. Redox modulation of heat shock protein expression by acetylcarnitine in aging brain Relationship to antioxidant status and mitochondrial function. Antioxid Redox Signal 8 404-416. 

Hainaut, P. and Miller, J. 1993. Redox modulation of p53 conformation and sequence-specific DNA binding. Cancer Res. 53, 4469 1473. 

Bigelow, D. J., and Squier, T. C. 2005. Redox modulation of cellular signaling and metabolism through reversible oxidation of methionine sensors in calcium regulatory proteins. Biochim. Biophys. Acta 1703 121-134. 

Sims, C., and Harvey, R. D. 2004. Redox modulation of basal and beta-adrenergically stimulated cardiac L-type Ca2+ channel activity by phenylarsine oxide. Br. J. Pharmacol. 142 797-807. 

Todorovic SM, Meyenburg A, Jevtovic-Todorovic V (2004) Redox modulation of peripheral T-type Ca channels in vivo alteration of nerve injury-induced thermal hyperalgesia. Pain 109 328-339... 

Campbell DL, Stamler JS, Strauss HC. 1996. Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. J Gen Physiol 108 277-293. 

DiChiara TJ, Reinhart PH. 1997. Redox modulation of hslo Ca2+-activated K+ channels. J Neurosci 17 4942-4955. 

Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF, et al. 1994. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 13 929-936. 

Physico-chemical change environment/medium, redox modulation, morpholog-ical/shape/structural modification... 

Monteiro, H.P. and Stem, A., Redox modulation of tyrosine phosphorylation dependent signal transduction pathways. Free Radical Biol. Med., 21, 323, 1996. 

Volume 4 is dedicated to three important topics Catalysis (Part 4.1), Heterogeneous Systems (Part 4.2), and Gas Phase Systems (Part 4.3). The six chapters of Part 4.1 cover the most important aspects of electron transfer catalysis, from fundamental concepts to organic synthesis, from carbon dioxide fixation to protein catalysis, from redox modulation to biomimetic catalysis. Part 4.2 deals with the basic aspects and the latest developments in electron transfer on semiconductors, dye-sensitized electrodes, mono- and multilayers, intercalated compounds, zeolites, micelles and related systems. Part 4.3 covers gas phase systems, from atoms to small molecules, exciplexes, and supermolecules. 

Figure 5. Recognition and redox modulation of flavin by (a) diacyldiamnopyridine receptors and (b) diaminotriazine-based receptors [25],...

To further emphasize the double face (Janus face) of the molecule, it has been recently demonstrated that the transfer of a NO group to cysteine sulfhydryls on proteins, known as S-nitrosylation, is a ubiquitous regulatory reaction. It represents a form of redox modulation in diverse tissues. Nitrosylated proteins are relevant in many processes ranging from signal transduction, DNA repair, host defence, and blood pressure control to ion channel regulation and neurotransmission [56]. 

Fuchs J, Zollner TM, Kaufmann R and Podda M, Redox-modulated pathways in inflammatory skin diseases. Free Radic Biol Med 30(4) 337-53,2001. 

Posttranslational regulation of glutamate transporters includes changes in cell surface expression due to trafficking between the plasma membrane and intracellular compartments, and modulation of transport activity by direct phosphorylation, redox modulation of sulfhydryl groups and inhibition by arachidonic acid and other ci5-polyunsaturated fatty acids. 

Rahman, I., Marwick, J., and Kirkham, P. (2004). Redox modulation of chromatin remodehng impact on histone acetylation and deacetylation, NF-kB and pro-inflammatory gene expression. Biochem Pharmacol 68, 1255-67. 

Gopalakrishna R, Chen Z-H, Gundimeda U. 1997a. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione Its role in inhibition of tumor promotion. Arch Biochem Biophys 348(l) 37-48. 

Jamba L, Nehru B, Bansal MP. 1997. Redox modulation of selenium binding proteins by cadmium exposures in mice. Mol Cell Biochem 177 169-175. 

Figure 15. Branched, trinuclear Ru-alkyne constructs exhibiting redox-modulated cubic NLO responses.

J. Fuchs H. Schofer, Redox Modulation of Signal Transduction and Gene Expression in HIV Infection The Role of the Antioxidant Lipoate. In Lipoic Add In Health and Disease J. Fuchs, L. Packer, G. Zimmer, Eds. Marcel Dekker, Inc. New York, 1997. 

Redox modulation through TT-stacking and donor atom-77 interactions 326... 

Redox modulation and specific binding applied to the design of molecular devices 328... 

Redox modulation through rr-stacking and donor atom-ir interactions... 

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