Redox signaling, modulation

H. Kimura, Y. Nagai, K. Umemure, and Y. Kimura, Physiological roles of hydrogen sulfide synaptic modulation, neuroprotection, and smooth muscle relaxation. Antioxidants Redox Signaling 7, 795-803 (2005). 

Calabrese Y, Colombrita C, Sultana R, Scapagnini G, Calvani M, Butterfield DA, Stella AM. 2006c. Redox modulation of heat shock protein expression by acetylcarnitine in aging brain Relationship to antioxidant status and mitochondrial function. Antioxid Redox Signal 8 404-416. 

Dulak, J., Jozkowicz, A., Foresti, R., Kasza, A., Frick, M., Huk, L, Green, C.J., Pachinger, O., Weidinger, F., Motterlini, R. (2002). Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxid. Redox Signal. 4 229 0. 

Sethi, J.M., Otterbein, L.E., Choi, A.M.K. (2002). Differential modulation by exogenous carbon monoxide of TNF-a stimulated mitogen-activated protein kinase in rat pulmonary artery endothelial cells. Antioxid. Redox Signal. 4 241-58. 

Soares, M.P., Usheva, A., Brouard, S., Berherat, P.O., Gunther, L., Tohiasch, E., Bach, F.H. (2002). Modulation of endothelial cell apoptosis by heme oxygenase-1-dervived carbon monoxide. Antioxid. Redox Signal. 4 321-9. 

Watson RW Redox regulation of neutrophil apoptosis. Antioxid Redox Signal 2002 4 97-104. Ashkenazi A, Dixit VM Death receptors Signaling and modulation. Science 1998 281 1305-1308. 

Serrero, G. and Lu, R., Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells, Antioxid. Redox Signal, 3 (6), 969-979, 2001. 

Okuyama H, Yoshida T, Son A, Oka S, Wang D, Nakayama R, Masutani H, Nakamura H, Nabeshima Y, Yodoi J. 2009. Thioredoxin binding protein 2 modulates natural killer T cell-dependent innate immunity in the liver Possible link to hpid metabolism. Antioxid Redox Signal 11 2585-2593. 

Wilson JX. Mechanism of action of vitamin C in sepsis Ascorbate modulates redox signaling in endothelium. Biofactors, 35 5-13 (2009). 

Fig. 4. EPR redox titration of ZJ. vulgaris Fepr protein at pH 7.5 of S = J components with dithionite and ferricyanide in the presence of mediators, [from (ZZ)]. ( , ) The Fepr protein-fingerprint signal (the 3+ state) monitored at g = 1.825 (O, ) signal with aU < 2 (the 5+ state) monitored atg = 1.898 ( , ) Titration in two directions starting from the isolated protein, which corresponds approximately to the top of the bell-shaped curve. ( , O) A titration starting from the fully preoxidized state. EPR conditions microwave frequency, 9.33 GHz microwave power, 13 mW modulation amplitude, 0.63 mT temperature, 15 K.

This review reports the more recent evidence for the ability of P-carotene and other carotenoids to modulate cell signaling related to cell growth and implicated in a lot of pathological events, including cancer, inflammation, and atherosclerosis by both redox and non-redox mechanisms. 

---