Recovery after stroke

Thored P, Arvidsson A, Cacd E, Ahlenius H, KaUur T, Darsaha V, Ekdahl CT, Kokaia Z, LindvaU O (2006) Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells 24 739-747... 

Furlan M, Marchal G, Viader F, Derlon JM, Baron JC. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol. 1996 40 216-226. 

Despite the limitations of fMRI outlined above, fMRI studies have shown similar findings to those of positron emission tomography studies in recovery after stroke (Yozbatiran and Cramer 2006 Rijntjes 2006). Increased ipsilateral primary sensorimotor cortical activity with posterior displacement of the ipsilesional focus of activity, bilateral supplementary motor area activation and premotor cortical activation occurs after stroke with use of the affected hand in comparison with use of the unaffected hand (Weiller et al. 1992 Cramer et al. 1997 Cao et al. 1998 Pineiro et at 2001). Specifically, in patients with capsular or other subcortical stroke, good recovery is related to enhanced recruitment of the lateral premotor cortex of the lesional hemisphere and lateral premotor and, to a lesser extent, primary sensorimotor and parietal cortex of the contralateral hemisphere (Gerloff et al. 2006). 

Yozbatiran N, Cramer SC (2006). Imaging motor recovery after stroke. Neuroradiology 3 482-488... 

Menniti F, Ren J, Coskran T et al (2009) PDE5A inhibitors improve functional recovery after stroke in rats optimized dosing regimen and implications for mechanism. J Pharmacol Exp Ther 331 1-9... 

Zhang R, Wang Y, Zhang L et al (2002) Sildenafil (viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 33 2675-2680... 

Brown, J.A. et al. Motor cortex stimulation for enhancement of recovery after stroke case report. Neurol. Res., 2003,25 815-818. 

Cardiovascular There is no evidence at present to support the use of amfetamine to enhance recovery after stroke. Despite a trend to improved motor function, doubts remain over its safety and it has significant hemodynamic adverse effects, the consequences of which are unknown. Furthermore, there are insufficient data from which to draw conclusions regarding the effects of... 

---