Recombination activating genes

Corazza, N., Eichenberger, S., Eugster, H.P. and Mueller, C. (1999) Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2( / ) mice upon transfer of CD4(+)CD45RB(hl) T cells. Journal of Experimental Medicine 190,1479-1492. 

TCDD causes bone marrow hypocellularity, with specific decreases in the total number of hematopoietic stem cells (HSC) and lymphocyte precursors.42 16 Exposure to TCDD also diminishes mRNA levels of recombination activating gene-1 and terminal deoxy-nucleotidyl transferase in bone marrow cells.47 The best characterized effect of TCDD on bone marrow is the impaired maturation of B cells. A single dose of TCDD causes a transient, time- and dose-dependent, and developmental stage-specific impairment in B cell maturation, with mature B cells affected first, followed by depletion of B cell progenitors.45-46... 

Bernstein, R.M., Schluter, S.E, Bernstein, H., Marchalonis, J.J. (1996). Primordial emergence of the recombination activating gene 1 (RAG1) sequence of the complete shark gene indicates homology to microbial integrases. Proc. Natl. Acad. Sci. USA 93,9454-9459. 

Hansen, J.D. Kaattari, S.L. (1995). The recombination activating gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss) cloning, expression and phylogenetic analysis. Immunogenetics 42, 188-195. 

Recombination, 136 Recombination activating genes (RAG1, RAG2), 19-22 Recombination signal sequences (RSS), 11-13, 18-22 Retinoic acid, 100, 104, 107, 108, 111 receptors, 108 Ribozymes, 160,164 evolution, 176 hammerhead, 162 Rhizobium, 199, 205, 210,211 RNA,... 

Yehuda AB, Friedman G, Wirtheim E, Abel L, Globerson A. Checkpoints in thymocytopoiesis in aging expression of the recombination activating genes RAG-1 and RAG-2. Meeh Ageing Dev 1998 102 239-247. 

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