Recombinant human thyroid stimulating hormone

Recombinant human thyroid stimulating hormone TSH receptors... 

Bockmann J, Winter C, Wittkowski W, Kreutz MR, Bockers TM (1997) Cloning and expression of a brain-derived TSH receptor. Biochem Biophys Res Commun 238 173-1780 Castagiola A, Swillens S, Niccoli P, Dumont JE, Vassart G, Ludgate M (1992) Binding assay for thyrotropin receptor autoantibodies using the recombinant receptor protein. J Clin Endocrinol Metab 75 1540-1544 Cole ES, Lee K, Lauziere K et al. (1993) Recombinant human thyroid stimulating hormone development of a biotech-... 

Ohio State University Recombinant human thyroid-stimulating hormone Liothyronine Levo thyroxine Thyroglobulin Anti-thyroglobulin antibody Thyroid-stimulating hormone (Thyrotropin)... 

Rosario PW, Borges MA, Purisch S. Preparation with recombinant human thyroid-stimulating hormone for thyroid remnant ablation with is associated with lowered radiotoxicity. J Nucl Med 2008 49(11) 1776-82. 

However, these same characteristics make lithium a useful adjunct in the treatment of hyperthyroidism with i l. A 39-year-old woman with Graves disease who may have developed thyrotoxicosis secondary to treatment with amiodarone, an iodine-rich medication [92 ]. She was administered lithium 900mg/day for 12 days to increase uptake. When this was combined with two doses of 0.9 mg of recombinant human thyroid stimulating hormone (rhTSH), there was a fivefold increase in uptake [92 ]. In a retrospective study of 204 hyperthyroid patients (n = 163 Graves disease, n = 26 toxic multinodular goiter, and n=15 solitary toxic thyroid adenoma), 103 patients received alone (median dose 558 MBq) and 101 received 1 with lithium (median... 

Recombinant form of human thyroid-stimulating hormone (rhTSH). Used diagnostically for serum thyroglobulin testing. 

Thyrotopin alfa, thyroid stimulating hormone (TSH), human recombinant, produced in CHO cells... 

Thyrotopin alia, thyroid stimulating hormone (TSH), human recombinant, produced in CHO cells Vivotif Berna Typhoid vaccine/Swiss [BIO] Typhoid vaccine live oral Ty21a [FDA] Salmonella typhi vaccine [SY] Vaccinum Febris Typhoidis Vivum Perorale (Stirpe Ty 21a) [SY Latin] Ty21a typhoid vaccine [SY] Typhoral [TR in Germany] NDC 58337-0003-01 [NDC]... 

Thyrotrophin is native thyroid-stimulating hormone. Recombinant human thyrotrophin is called thyrotropin. 

FSH is a member of a superfamily of proteins, all structurally related. which includes luteinizing hormone (LH), chori->inlc gonadotropin, and thyroid-stimulating hormone (TSH). It is u heterodimer, the a subunit contains 92 amino acids, and the subunit contains 111 amino acids. The protein IS rather heavily glycosylated and has a molecular mass of approximately 33 kDa. The traditional source for isolation t l FSH was postmenopausal urine, which provided a preparation that was less than 3% pure and wa.s signiricantly contaminated by LH. The recombinant human FSH (rhFSH) is produced in a mammalian cell line, the CHO. 

Thyrotropin is an anterior pituitary hormone that stimulates the thyroid to produce and synthesize thyroxine (T4), triiodothyronine (T3), and thyroglobulin. Thyrotropin alpha is a commercially available analog of TSH that is used to help detection of metastatic differentiated thyroid carcinoma it is also known as recombinant human TSH (rhTSH). 

Iodide uptake after stimulation with TSH is sufficient in most differentiated thyroid cancers to utilize (3-emit-ting radioactive iodine for the treatment of residual and metastatic disease. Elevated serum TSH (which can be achieved by thyroid hormone withdrawal after thyroidectomy or administration of recombinant human TSH)... 

The maximal stimulation of uptake by thyroid tissue can be achieved by increasing serum TSH concentration above 25—30pU/ml. This can be achieved by thyroid hormone withdrawal, or by administration of recombinant human TSH (rhTSH), the latter enables sufficient iodine uptake while avoiding hypothyroidism and reducing total body radiation exposure (Pacini et al, 2006). 

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