Recombinant drugs production systems

Products/technologies These include a combinatorial biology drug discovery platform for the development, improvement, and production of therapeutic proteins recombinant protein production systems for monomeric, dimeric, and heteromeric proteins. Neugenesis combinatorial biology technology (the... 

To a significant extent these new options of biotechnology have already been exploited in the health sector (new types of drugs and diagnostic tools), whereas practical applications are emerging at lower speed in other sectors, such as nutrition, environment, raw material supply, or specialty chemicals. New biotechnological production systems based on mammalian cell cultures are in use, e.g., for the manufacture of recombinant therapeutic proteins and antibodies. 

Stirred tank models have been widely used in pharmaceutical research. They form the basis of the compartmental models of traditional and physiological pharmacokinetics and have also been used to describe drug bioconversion in the liver [1,2], drug absorption from the gastrointestinal tract [3], and the production of recombinant proteins in continuous flow fermenters [4], In this book, a more detailed development of stirred tank models can be found in Chapter 3, in which pharmacokinetic models are discussed by Dr. James Gallo. The conceptual and mathematical simplicity of stirred tank models ensures their continued use in pharmacokinetics and in other systems of pharmaceutical interest in which spatially uniform concentrations exist or can be assumed. 

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