Combinatorial biology

Comb copolymers, 7 610t Combed yarn, 11 178 Combes synthesis, of quinolines, 21 189 Combicat, 7 387, 392 Combinational libraries, 7 382 characterization, 7 404-405 composition gradient libraries, 7 407 design, 7 399-400 fabrication, 7 414-419 temperature gradient libraries, 7 407—408 thickness gradient libraries, 7 406 Combination electrodes, 14 30 Combination vaccines, 25 504-505 Combinatorial biology, 16 414 Combinatorial biosynthesis, 15 301-302, 305... 

Profile A private company, Neugenesis was founded in 1992 by several key individuals who recognized the potential commercial value of Neurospora for biotechnology applications. It has nine employees and occupies a 1600 square foot facility for its headquarters and R D facilities. The company uses proprietary combinatorial biology technology to discover and develop new biotherapeutics, both alone and in partnership with other biopharmaceutical companies. 

Products/technologies These include a combinatorial biology drug discovery platform for the development, improvement, and production of therapeutic proteins recombinant protein production systems for monomeric, dimeric, and heteromeric proteins. Neugenesis combinatorial biology technology (the... 

Peterson TC, Divetse bioactivicies from actinomyccte combinatorial biology libraries. Presentation at the Sixth Conference on the Genetics and Molecular Biology of Industrial Microorganisms, Bloomington, Indiana 1996. 

Nature uses combinatorial biology for antibody selection, and this general concept led scientists to introduce phage display in a combinatorial fashion to make peptides. ... 

Sidhu, S. S., Bader, G. D., and Boone, C. 2003. Fimctional genomics of intracellular peptide recognition domains with combinatorial biology methods. Curr Opin Chem Biol, 7 97-102. 

Large data sets such as screening data or results obtained by combinatorial experiments are made up of a large number of data records. Hence a data record may represent a chemical reaction or substance, for example its corresponding variables will define the corresponding reaction conditions or biological activities. Depending on the dimensionality or data type of the information, one-, two-, multidimensional, or specific data types can be identified. 

Chemoinformatics (or cheminformatics) deals with the storage, retrieval, and analysis of chemical and biological data. Specifically, it involves the development and application of software systems for the management of combinatorial chemical projects, rational design of chemical libraries, and analysis of the obtained chemical and biological data. The major research topics of chemoinformatics involve QSAR and diversity analysis. The researchers should address several important issues. First, chemical structures should be characterized by calculable molecular descriptors that provide quantitative representation of chemical structures. Second, special measures should be developed on the basis of these descriptors in order to quantify structural similarities between pairs of molecules. Finally, adequate computational methods should be established for the efficient sampling of the huge combinatorial structural space of chemical libraries. 

Combinatorial chemistry (Section 27.18) A method for carrying out a large number of reactions on a small scale in the solid phase so as to generate a library of related compounds for further study, such as biological testing. 

Biologically important arylaimnes, various kinds of heterocycles, and macrocyclic potmds have been prepared by using resin-botmd nitro halo compotmds via S Such a process is very important for combinatorial synthesis of biologically important potmds Typical examples are presented in Eqs 9 13-9 31... 

Colony-stimulating Factors Combinatorial Chemistry Compartment Competitive Antagonists Complement System Complement-type Repeat Complex Disease Compound Libraries Compound Optimization Computational Biology Computerized Tomography COMT... 

Recently it has been shown that the microwave-assisted decoration of the 2(lff)-pyrazinone scaffold can allow an easy introduction of different substituents at the C-3 and even to the less reactive C-5 position [29]. Taking full advantage of combinatorial principles, some of these pathways were transferred to microwave-enhanced solid-phase chemistry, opening the way for the generation of many biologically interesting structures [108]. 

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