Recognition mode

A critical consequence of the above studies is that they allowed groove binding to be ruled out as a dominant sapphyrin-DNA recognition mode. This is because in the presence of sapphyrin 7,(1) the same spectral features were seen for both ss-and dsDNA, yet (2) only the latter contains a well-defined set of major and minor grooves. 

Ruling out intercalation as a critical recognition mode proved harder on a spectroscopic basis. Thus resort was made to a biochemical Topoisomerase I assay. This assay, which sapphyrin passed in a negative sense, can be used to detect the unwinding that is considered diagnostic of intercalation. ... 

Many biologically important interactions at the molecular level involve carbohydrates and proteins, and there is no natural recognition mode that is more intimate and specific. 

Neuheuser, X, Hess, B. A., Reutel, C., and Weber, E., Ab initio calculations of supramolecular recognition modes. Cyclic versus noncyclic hydrogen bonding in the formic acid/formamide system, J. Phys, Chem, 98, 6459-6467 (1994). 

Fpg recognition mode of FapyG residue and mechanism of catalyzing N-glycosidic bond cleavage... 

DNA recognition mode in which the lesion is first recognized and verified in an ATP-dependent manner. Lesion removal then occurs by two latent endonucleases that are recruited to NER complexes in a subsequent step. In contrast to BER, damage recognition and incision activities do not reside in the same polypeptide, likely allowing NER to be a more adaptable system for lesion recognition and repair. 

In humans, the neocortex (the gray matter) regulates the biological information into emergent pattern recognition modes that make a mind. See R. Kurzweil, How to Create a Mind. Penguin Books, New York, 2012. 

Numerous examples of peptide hydrolysis have been achieved with the assistance of metal ions/metal complexes, including Zn, Co, Zr, Cu, Ni, Mo, Pd, and Pt. Detailed information can be found in a number of excellent and comprehensive review articles written on this subject [32—48]. According to the recognition mode, the site-selective peptide/protein degradation can be achieved in two ways a direct metal-peptide side chain interaction or a promoter s recognition site-peptide side chain interaction. 

Further work to clarify the exact mechanism by which shape and polarity matching influences co-crystal formation will undoubtedly lead to improvements in the co-former selection strategy presented here. Experimental results that apparently contradict these principles may uncover new supramolecular recognition modes, as illustrated by the co-crystallisation of steroids with aromatic compounds, or help identify further factors that need to be considered in co-crystal design. 

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