Biomimetic receptors

Beer PD, Bayly SR (2005) Anion Sensing by Metal-Based Receptors. 255 125-162 Bertini L, Bruschi M, de Gioia L, Fantucci P, Greco C, Zampella G (2007) Quantum Chemical Investigations of Reaction Paths of Metalloenzymes and Biomimetic Models - The Hydrogenase Example. 268 1-46 Bier FF, see Heise C (2005) 261 1-25... 

Rather than using the protein molecule as a whole, the imprinting of selected protein epitopes may present a more practical approach. Imprints of such patches may then act as receptors for these parts of the protein. It could be shown that an MIP imprinted with a tetrapeptide was able to recognize not only the template but also a protein bearing the same 3-amino acid terminus as the peptide template [129]. If this approach proves to be successful in other cases as well, MI-based recognition will no longer be limited to small molecules. The result will be even more antibody like biomimetic polymers. 

The closely related structures show completely different microbial uptake characteristics. The 3D structures described above show distinct different orientation of the backbone amide (tangental in type 1 versus radial in type 2), which can be explained by the interactions that take place between the FhuA receptor and the ferrichrome siderophore -As mentioned, the second coordination sphere of natural ferrichrome in FhuA receptor is very sensitive to the distance and orientation between a proton donor and the proton acceptor, therefore the orientation of the amide groups in the biomimetic siderophore plays a crucial role in receptor recognition. 

AU the synthesized compounds, regarchess of their probe s size or charge, display microbial activity in P. putida similar to that of the biomimetic analogs lacking the probe. These results provide an indication that the epical site in the tetrahedral carbon-based templates is available for attachment of chemical moieties without hampering iron(in) coordination and receptor recognition. 

Lyotropic liquid-crystalline nanostructures are abundant in living systems. Accordingly, lyotropic LC have been of much interest in such fields as biomimetic chemistry. In fact, biological membranes and cell membranes are a form of LC. Their constituent rod-like molecules (e.g., phospholipids) are organized perpendicularly to the membrane surface yet, the membrane is fluid and elastic. The constituent molecules can flow in plane quite easily but tend not to leave the membrane, and can flip from one side of the membrane to the other with some difficulty. These LC membrane phases can also host important proteins such as receptors freely floating inside, or partly outside, the membrane. 

The goal in Volume 4 of Advances in Supramolecular Chemistry remains the same as for previous volumes to present a broad range of supramolecular science recorded by an international panel of distinguished researchers. Contributions in this volume span the scientific range from electronic device development to novel synthetic receptor molecules to biomimetic ion channels. 

The main limitations associated with the application of MIPs, instead of antibodies or other biomimetic receptors, in ILAs are summarized as follows ... 

In spite of all their advantages, sensitivity and selectivity, bio-sensors, however, do possess disadvantages connected with thermal and timely instability, high cost of bio-receptors and the need to add substrates in the solution under analysis as signal-generating substances. Some attempts to synthesize and use as receptors chemical organic catalytic systems, which will ensure the required selectivity and response rate, have become the basis for developing enzyme-free sensors [11], or biomimetic sensors. 

Dillow, A. K., Ochsenhirt, S. E., McCarthy, J. B., et al. Adhesion of alpha 5 beta 1 receptors to biomimetic substrates constructed from peptide amphiphiles. Biomaterials 22 1493—1505, 2001. 

Dithiocarbamates, in Ru and Os half-sandwiches, 6, 493 Dithiocarbenes, Pt complexes, 8, 439 Dithiocarboxy ligands, in molybdenum carbonyls, 5, 447 Dithiolate-bridged compounds in dinuclear iron compounds with Fe-Fe bonds, 6, 238 as iron-only hydrogenase biomimetic models, 6, 239 Dithiolate diamides, with Zr(IV), 4, 784 Dithiolene—uranium complexes, synthesis and characterization, 4, 212 Ditopic receptors, characteristics, 12, 489 Ditungsten complexes, associated reactions, 5, 748 Divinyllead diacetates... 

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