Receptors agonists and antagonists

Table 10. GABA and GABA Receptor Agonists and Antagonists...

Adenosine Receptors. Table 2 Affinity of commonly used adenosine receptor agonists and antagonists for defining pharmacologically adenosine receptor subtypes... 

Parrill AL, Sardar VM, Yuan H (2004) Sphingosine 1-phosphate and lysophosphatidic acid receptors agonist and antagonist binding and progress toward development of receptor-specific ligands. Semin Cell Dev Biol 15 467-476... 

Because of the complexities resulting from the use of these relatively broadly acting COX inhibitors, the use of selective PG synthase inhibitors or receptor agonists and antagonists could provide therapeutic alternatives devoid of these side effects and therefore with therapeutic value. At this point, there are no potent and selective PG synthase inhibitors or receptor... 

Coffman RL, et al (2007) Therapentic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat med 13(5) 552-559... 

Eglen, RM and Watson, N (1996) Selective muscarinic receptor agonists and antagonists. Pharmacol. Toxicol. 78 59-78. 

Leurs, R, Blandina, P, Tedford, C and Timmerman, H (1998) Therapeutic potential of histamine H3 receptor agonists and antagonists. Trends Pharmacol. Sci. 19 177-183. 

J.J. and Svendsen, 0. Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers. Psvchopharmacoloav 81 199-207, 1983. 

Zimmerman DM, Leander JD. Selective opioid receptor agonists and antagonists research tools and potential therapeutic agents. J Med Chem 1990 33 895-902. 

Brown, J.H. and Taylor, P., Muscarinic receptor agonists and antagonists, in Goodman and Gilman s The Pharmacological Basis of Therapeutics, 9th ed., Hardman, J.G. and Limbird, L.E., Eds., McGraw-Hill, New York, 1996, chap. 7. 

Administration of H2-receptor agonists and antagonists in rats had no effect on sleep-wakefulness (Monti et al., 1986,1990). Although local application of impromidine (1 pg in 1 pi), an H2 receptor agonist, into the preoptic region of the cat mimicked the effects of HA in inducing wakefulness, local application of impromidine (0.2 pg in 0.25 pi) in the pontine tegmentum had little effect. 

Gobert, A, Lejeune, F., Rivet, J. M. et al. (1995). Modulation of the activity of central serotoninergic neurons by novel serotoniniA receptor agonists and antagonists a comparison to adrenergic and dopaminergic neurons in rats. J. Pharmacol. Exp. Ther. 273, 1032-46. 

Monti, J. M., Jantos, H. Monti, D. (2000). Dorsal raphe nucleus administration of 5-HTia receptor agonist and antagonists effect on rapid eye movement sleep in the rat. Sleep Res. Online 3, 29-34. 

LY 156735 is a [1-substituted analog of melatonin that has greater bioavailability than melatonin (Nickelsen et al. 2002). It is in an earlier stage of clinical trials in initial trials, it reduced the sleep onset time in patients with moderate sleep-onset insomnia. Several other specific melatonin receptor agonists and antagonists are in development (Rivara et al. 2005 Zlotos 2005) and presumably will be clinically tested over the next few years. 

Khroyan T.V., Platt D.M., Rowlett J.K., Spealman R.D. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology (Berlin). 168 124, 2003. 

Portoghese P, Moe S, Takemori A. A selective deltal opioid receptor agonist derived from oxymorphone evidence for separate recognition sites for deltal opioid receptor agonists and antagonists. 

Kemp, J. A., Marshall, G. R., and Woodruff, G. N. (1986) Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation. Br. J. Pharmacol. 87,677-684. 

Berge, O. G. (1982) Effects of 5-HT receptor agonists and antagonists on a reflex response to radiant heat in normal and spinally transected rats. Pain, 13 253-266. 

The indole analogue GR 65630 (34) has been used as a radioactive ligand in studies of binding of various 5-HT3 receptor agonists and antagonists [28],... 

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