Receptors plasticity

Receptor plasticity could be invoked as the underlying common trait of multiple receptors. For example, although the multiple adrenergic isoreceptors are similar, they react to the common neurotransmitter norepinephrine (2.4) in a quantitatively different manner. They also show a drug specificity that varies from organ to organ and differs in various species of animals. In subsequent chapters of this book, receptor multiplicity as the rule rather than the exception will become amply evident. It is to be hoped that, in time, the comparison of isoreceptor molecular structures will provide precise criteria for their differentiation. 

GABAA-Receptor Plasticity during Long-Term Exposure to and Withdrawal from Progesterone... 

Mohler H (2007) Molecular regulation of cognitive functions and developmental plasticity impact of GABAa receptors. Neurochem 102 1-12... 

ChEs control the duration of ACh-mediated action on post-synaptic receptors in cholinergic synapses, and have non-hydrolytic roles in nervous systems development and plasticity. 

Berger S, Wolfer DP, Selbach O et al (2006) Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci USA 103 195-200... 

Long-term potentiation (LTP) is a synaptic plasticity phenomenon that corresponds to an increase in the synaptic strength (increase in the post-synaptic response observed for the same stimulation of the presynaptic terminals) observed after a high frequency stimulation (tetanus) of the afferent fibres. This increased response is still observed hours and even days after the tetanus. The phenomenon is often observed at glutamatergic synapses and involves, in most cases, the activation of the V-methyl D-aspartate (NMDA) subtype of ionotropic glutamate receptors. 

Herz J, Chen Y (2006) Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev 7 850-859... 

Neurotrophins (NGF brain-derived neurotrophic factor, BDNF neurotrophin-3, NT-3 NT-4 NT-6) are important regulators of neural survival, development, function, and plasticity of the vertebrate nervous system [1]. Neurotrophins generally function as noncovalently associated homodimers. They activate two different classes of receptors, through which signaling pathways can be activated, including those mediated by Ras and members of the cdc42/rac/rho G protein families, MAP kinase, PI-3 kinase, and Jun kinase cascades. 

Di- and mono-esters of phthalic acid, an ortho-dicarboxylic acid derivative of benzene. These compounds are widely used as industrial plasticizers to coat polyvinylchloride surfaces of plastics used in food packaging and medical devices (iv drip bags, blood storage bags, etc.) and are common environmental contaminants. Several phthalate mono-esters are peroxisome proliferator chemicals and can activate the peroxisome proliferator-activated receptor PPAR. 

It is well established that the autonomic nervous system shows marked plasticity. The expression of cotransmitters and receptors shows dramatic changes during development and ageing, in nerves that remain... 

NMDAR. An ionotropic receptor for glutamate. It plays a critical role in synaptic plasticity mechanisms and thus is necessary for several types of learning and memory. 

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