Receptor diversity

Both AMPA and NMDA receptors are multimeric, probably tetrameric, assemblies of various molecularly distinct subunits, giving rise to large receptor diversity. For AMPA receptors this is achieved by assembling the... 

Buck L. (1993). Receptor diversity and spatial patterning in the mammalian olfactory system. In The Molecular Basis of Smell and Taste Transduction (Chadwick D., et al., eds). John Wiley, London, Ciba Symposium 179, pp. 51-67. 

Whiteaker, P., Marks, M.J., Grady, S.R. et al. Pharmacological and null mutation approaches reveal nicotinic receptor diversity. Eur. J. Pharmacol. 393 123, 2000. 

Russek, S. J. (1999) Evolution of GABAa receptor diversity in the human genome. Gene 227, 213-222. 

The T cell receptor diversity arises by comparable mechanisms, and the a(3 receptor for example may exist in at least 8 x 106 and probably many more different combinations. 

Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L Origin and T cell receptor diversity of Foxp3+CD4+CD25+... 

GC exert their regulatory effects on the HPA system via two types of corticosteroid receptors the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) (Reul and De Kloet 1985). GRs occur everywhere in the brain but are most abundant in hypothalamic CRH neurons and pituitary corticotropes. MRs, in contrast, are highly expressed in the hippocampus and, at lower expression levels, in hypothalamic sites involved in the regulation of salt appetite and autonomic outflow. The MR binds GC with a tenfold higher affinity than does the GR (Reul and De Kloet 1985). These findings on corticosteroid receptor diversity led to the working hypothesis that the tonic influences of corticosterone... 

De Beilis MD, Baum AS, Birmaher B, Keshavan MS, Eccard CH, Boring AM, Jenkins FJ, Ryan ND (1999) A.E. Bennett Research Award. Developmental traumatology. Part 1 Biological stress systems [see comments]. Biol Psychiatry 45 1259-1270 de Kloet ER, Joels M, Oitzl M, Sutanto W (1991) Implication of brain corticosteroid receptor diversity for the adaptation syndrome concept. Methods Achiev Exp Pathol 14 104-132 Delahanty DL, Raimonde AJ, Spoonster E (2000) Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims. Biol Psychiatry 48 940-947... 

Costa E. From GABAa receptor diversity emerges a unified vision of GABAergic inhibition. Annu Rev Pharmacol Toxicol 1998 38 321-350. 

Bonner, T.I. (1989) The molecular basis of muscarinic receptor diversity. Trends Neurosci 12 148—151. 

With one exception, all the mechanisms used by B cells to generate antibody diversity are also used by T cells to generate T-cell receptor diversity. The one mechanism that does not appear to operate in T-cell receptor diversification is somatic hypermutation. This is presumably because mutation would be likely to generate killer T cells that would wantonly attack self-molecules. This is much less of a problem for B cells, since most self-reactive B cells could not be activated without the aid of specific helper T cells. 

Mohler H. 2006. GABA(A) receptor diversity and pharmacology. Cell Tissue Res 326 505-516. 

G. Glusman, S. Clifton, B. Roe, D. Lancet. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17 recombinatorial events affecting receptor diversity. Genomics, 37 (2), 147-160, 1996. 

Hahn, M.E. Aryl hydrocarbon receptors diversity and evolution. Chem.-Biol. Interact. 141 131-160, 2002. 

Receptor diversity in fish vs. mammals Implications for investigation of fish as targets and models in toxicology... 

Cull-Candy SG, Brickley SG, Misra C, Feldmeyer D, Momiyama A, Farrant M (1998) NMDA receptor diversity in the cerebellum identification of subunits contributing to functional receptors. Neuropharmacology 57 1369-1380. 

Buller AL, Larson HC, Schneider BE, Beaton JA, Morrisett RA, Monaghan DT (1994) The molecular basis of NMDA receptor diversity is predicted by subunit composition. J. Neurosci., 14, 5471-5484. 

Hartman DS, Civeiii O. Dopamine receptor diversity moiecuiar and pharmacoiogicai perspectives. Prcg Drug Res 1997 48 173-194. 

Gu YZ, Hogenesch JB, Bradfield CA (2000) The PAS superfamily sensors of enviromnental and developmental signals. Annu Rev Pharmacol Toxicol 40 519-561 Hahn ME (2001) Dioxin toxicology and the aryl hydrocarbon receptor insights from fish and other non-traditional models. Mar Biotechnol (NY) 3 S224—S238 Hahn ME (2002) Aryl hydrocarbon receptors diversity and evolution. Chem Biol Interact 141 131-160... 

Signaling from G Protein-Coupled Receptors Diversity of G Protein-Coupled Receptors... 

De Rosa, S. C., Herzenberg, L. A., and Roederer, M. 2001.11-color, 13-param-eter flow cytometry Identification of human naive T cells by phenotyp>e, function, and T-cell receptor diversity Nat. Med. 7 241-248. 

Hahn, M. E. (2002). Aiyl hydrocarbon receptors diversity and evolution. Chemico-Biological Interactions, 141, 131-160. 

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