Receptor-associated coactivator 3

Li H, Gomes PJ, Chen JD. 1997. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94 8479-84... 

ACTR/RAC3 and p/cip A receptor-associated cofactor 3 (RAC3) was cloned as a coactivator for the liganded receptor LBD (69) and found to be identical to another coactivator named ACTR, which was known to possess intrinsic HAT activity (70). Sequence comparison revealed a homology to the SRC-1 and TIFII members (69) therefore, it was also categorized in the SRC family. A closely related coactivator, the p300/CBP cointegrator associated protein (p/CIP), was found to interact with CBP and was required for the actions of CBP-dependent transcription factors (71). These members represent the third SRC family that functions as coactivators for RARs and RXRs, and possesses HAT activity. 

Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG. 1998. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand dependent fashion. Proc. Natl. Acad Sci. USA 95 7939 14... 

Interaction of the HAT coactivatorcomplex with the ligand-activated receptors is apparently transient as dissociation is believed to occur as a result of acetylation of one or more coactivators on lysine residues adjacent to the signature LXXLL motif (187). Subsequently, the activated receptor presumably recruits a second class of multi-protein, transcriptional coactivator complexes to the template, and this latter complex, referred to as the thyroid hormone receptor-associated protein (TRAP)... 

Lin, J., Puigserver, P., Donovan, J., Tarr, P., and Spiegelman, B. M. Peroxisome proliferator-activated receptor gamma coactivator Ibeta (PGC-lbeta ), a novel PGC-l-related transcription coactivator associated with host cell factor. J Biol Chem 277 (2002) 1645-1648. 

Glass CK, Rose DW, Rosenfeld MG (1997) Nuclear receptor coactivators. Curr Opin Cell Biol 9 222-232 Burris TP, Nawaz Z, Tsai M-J, O Malley BW (1995) A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors. Proc Natl Acad Sci USA 92 9525-9529... 

D receptors and their associated coactivators heat shock proteins. Additional possibilities include the glucocortocoid and mineralcorticoid receptors and a number of orphan receptors, e.g., the aryl hydrocarbon receptor. In the latter case, it has aheady been demonstrated that degradation can be effected by a thermally activated enediyne thus, a photochemical variant could be forthcoming. 

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