6- Receptor agonists pharmacological activity

Ap4A (Ap(4)A Pi,Ps-diadenosine tetraphosphate) is an endogenous agent used in synthetic form as a pharmacological tool in purine receptor classification studies. It is a PURINE p2 RECEPTOR AGONIST, particularly active at the pyrimidine-preferring receptor subtypes. Ap(4)A Ap4A. 

NMD A receptors are selectively activated by A/-methyl-D-aspartate (NMD A) (182). NMD A receptor activation also requires glycine or other co-agonist occupation of an allosteric site. NMDAR-1, -2A, -2B, -2C, and -2D are the five NMD A receptor subunits known. Two forms of NMDAR-1 are generated by alternative splicing. NMDAR-1 proteins form homomeric ionotropic receptors in expression systems and may do so m situ in the CNS. Functional responses, however, are markedly augmented by co-expression of a NMDAR-2 and NMDAR-1 subunits. The kinetic and pharmacological properties of the NMD A receptor are influenced by the particular subunit composition. 

Fride E, Mechoulam R. Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. Eur J Pharmacol 1993 231 313-314. 

Rothman R., France C., Bykov V. et al. Pharmacological activities of optically pure enantiomers of the K opioid agonist, U50,488 and its els diastereomer evidence for three K receptor subtypes. Em J. Pharmacol. 167 345, 1989. 

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