Agonist, pharmacological

Basic agonist pharmacology at NKxr, NK2r, or NK3r that is valid for most of bioassay is shown in Table 5. 

Martin JR, et al. 5-HT2C receptor agonists pharmacological characteristics and therapeutic potential. J Pharmacol Exp Ther 1998 286(2) 913-924. 

Drapeau G, Brochu S, Godin D, Levesque L, Rioux F, Mai ceau F (1993) Syntlretic C5a receptor agonists Pharmacology, metabolism and in vivo cai diovasculai and hematologic effects. Biochem Pharmacol 45 1289—99. 

Presynaptic and postsynaptic inhibition through Gj coupling Mu pharmacology most important Morphine is the prototype p agonist Pharmacology of morphine ... 

The actions of histamine are mediated through at least three distinct receptors defined pharmacologically by the actions of the respective agonists and antagonists. Reviews have been pubHshed (16,17). 

NMD A receptors are selectively activated by A/-methyl-D-aspartate (NMD A) (182). NMD A receptor activation also requires glycine or other co-agonist occupation of an allosteric site. NMDAR-1, -2A, -2B, -2C, and -2D are the five NMD A receptor subunits known. Two forms of NMDAR-1 are generated by alternative splicing. NMDAR-1 proteins form homomeric ionotropic receptors in expression systems and may do so m situ in the CNS. Functional responses, however, are markedly augmented by co-expression of a NMDAR-2 and NMDAR-1 subunits. The kinetic and pharmacological properties of the NMD A receptor are influenced by the particular subunit composition. 

Fig. 9. Correlation between binding and pharmacologic affinities where the dashed lines correspond to the theoretical correlation of 1 1 for a series of muscarinic receptor (a) antagonists, (1)—(9) and (b) agonists, (10)—(19). Correlation for the antagonists is essentially 1 1, deviating markedly from that...

Compounds that have agonistic properties at glutamate or aspartate receptors are also CNS stimulants, readily cause convulsions, and presumably could also be employed as analeptics. Three separate excitatory amino acid receptor subtypes have been characterized pharmacologically, based on the relative potency of synthetic agonists. These three receptors are named for their respective prototypical agonists A/-methyl-D-aspartate [6384-92-5]... 

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