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Receptor a-chain

Garcia-Montero AC, Jara-Acevedo M. Teodosio C. et al KIT mutation in mast cells and other bone marrow hematopoietic cell hneages in systemic mast cell disorders a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood 2006 108 2366-2372. Daley T, Metcalfe DD, Akin C Association of the Q576R polymorphism in the interleukin-4 receptor a chain with indolent mastocytosis limited to the skin. Blood 2001 98 880-882. [Pg.123]

A cardinal role for IL-4 in host protection against intestinal nematode infection was first shown in the H. polygyrus challenge model. Worm expulsion was delayed following treatment with anti-IL-4 or anti-IL-4 receptor monoclonal antibodies, while control treated animals successfully cleared infection (Urban et al., 1991b). Blockade of the IL-4 receptor effectively prevents the in vivo function of IL-4 and IL-13, as these two cytokines share the IL-4 receptor a-chain for signalling functions (Lin et al, 1995). In... [Pg.342]

The complement control protein superfamily - IL-2 receptor (a-chain)... [Pg.210]

FceRI receptor (a-chain) mapped to chromosome lq23 21... [Pg.74]

Banks, M. (1995) Soluble interleukin-5 receptor a chain binding assays use for screening and analysis of interleukin-5 mutants. Anal. Biochem. 230, 321-328. [Pg.142]

The crystal structure of human interleukin-4 (IL-4) bound to the ectodomain of the a-chain of the IL-4 receptor has been solved.34 The IL-4 receptor is a t5y)e I receptor. The ligand, IL-4, binds first with high affinity to the receptor a-chain and then the inter-... [Pg.110]

T. Hage, W. Sebald, and E Reinemer. Crystal structure of the interleukin-4 receptor a chain complex reveals a mosaic binding interface. Cell, 97, 271-281, 1999. [Pg.120]

The high-affinity receptor for IL-11 is composed of two subunits, IL-11 receptor a-chain (IL-llRa) and gpl30, the common subunit of the IL-6, CNTF, LIF, and OSM receptors. The IL-11 receptor-specific a chain shares homologies with the a chain of the CNTF and IL-6 receptors, confirming evolutionary conservation at the level of gene organization among the hematopoietic cytokine receptor family. ... [Pg.681]

Anderson DM, Kumaki S, Ahdieh M, et al. Functional characterization of the human interleukin-15 receptor a chain and close linkage of 1L15RA and 1L2RA genes. J Biol Chem 1995 270 29862-9. [Pg.723]

Caput D, Laurent P, Kaghad M, et al. Cloning and characterization of a specific interleukin IL-13 binding protein structurally related to the IL-5 receptor a chain. J Biol Chem 1996 271 16921-6. [Pg.725]

Kumald S, Armitage R, Ahdieh M, et al. Interleukin-15 up-regulates interleukin-2 receptor a chain but down-regulates its own high-affinity binding sites on human T and B cells. Eur J Immuno 1996 26 1235-9. [Pg.733]

A combined phase I/II trial for ricin conjugates with antibodies against the lymphocyte activation markers CD25 (the IL-2 receptor a-chain) or CD30 (a member of the TNF receptor superfamily, possibly involved among others in memory T cell development) for patients with Hodgkin s lymphoma showed some promise [146]. [Pg.1173]

Anti-CD4 (humanized hIgGl-CD4 modulating, non-depleting monoclonal antibody). Anti-CD4 monoclonal antibodies have been used in the treatment of rheumatoid arthritis, psoriasis, systemic lupus erythematosus, and multiple sclerosis. First dose reactions were observed (dyspnea, chills, hypotension [32]. Of note, the anti-IL-2 Receptor (a chain) antibodies dadi-zumab (Zenapax) and basiliximab (Simulect), widely studied in renal transplant recipients, do not induce cytokine release or first dose reactions [33]. [Pg.462]

Basiliximab is an immunosuppressive agent that blocks the interleukin-2 receptor a-chain, which is a critical pathway in allograft rejection. Basiliximab is indicated in the prophylaxis of acute organ rejection in patients receiving renal transplantation when used as part of an immunosuppressive regimen that includes cyclosporine and corticosteroids. [Pg.101]

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See also in sourсe #XX -- [ Pg.47 ]



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