Reactive oxygen species interactions

Radiolytic and Photolytic Production of Free Radicals and Reactive Oxygen Species Interactions with Antioxidants and Biomolecules... 

Analysis of Products Arising from the Interactions of Reactive Oxygen Species with Further Biomolecules of Low Molecular Mass 7 ... 

Bourne, L., CoUis, C. and Rice-Evans, C. (1994). The interaction of ruptured myocytes with low density lipoproteins. In Frontiers of Reactive Oxygen Species in Biolc and Medicine . (eds. K. Asada and T. Yoshikawa) pp. 469-470, Elsevier Science Pub. 

Spin trapping methods were also used to show that when carotenoid-P-cyclodextrin 1 1 inclusion complex is formed (Polyakov et al. 2004), cyclodextrin does not prevent the reaction of carotenoids with Fe3+ ions but does reduce their scavenging rate toward OOH radicals. This implies that different sites of the carotenoid interact with free radicals and the Fe3+ ions. Presumably, the OOH radical attacks only the cyclohexene ring of the carotenoid. This indicates that the torus-shaped cyclodextrins, Scheme 9.6, protects the incorporated carotenoids from reactive oxygen species. Since cyclodextrins are widely used as carriers and stabilizers of dietary carotenoids, this demonstrates a mechanism for their safe delivery to the cell membrane before reaction with oxygen species occurs. 

Certain bifunctional metal chelating agents have been used to investigate protein interactions by virtue of their ability to generate reactive oxygen species that affects protein structure in the immediate vicinity of their modification site. The following sections discuss two applications of such chelate labels, one of which cleaves peptide bonds while the other one causes covalent crosslinks to occur between interacting protein structures. 

As the superoxide radical is a precursor of the other reactive oxygen species and interacts with blood plasma components under physiological and pathological conditions as well, systems related to its generation are biologically relevant. It should be noted, however, that with respect to the initiation of lipid peroxidation as one of the main causes of oxidative cell damage, its own reactivity is very weak and that only in protonized form is its toxicity comparable to that of lipid peroxyl radicals [18]. 

The formation of nitric oxide in microsomes results in the inhibition of microsomal reductase activity. It has been found that the inhibitory effect of nitric oxide mainly depend on the interaction with cytochrome P-450. NO reversibly reacts with P-450 isoforms to form the P-450-NO complex, but at the same time it irreversibly inactivates the cytochrome P-450 via the modification of its thiol residues [64]. Incubation of microsomes with nitric oxide causes the inhibition of 20-HETE formation from arachidonic acid [65], the generation of reactive oxygen species [66], and the release of catalytically active iron from ferritin [67],... 

Davies and his co-workers [6,7] studied in detail the interaction of various reactive oxygen species with proteins. It was found that the hydroxyl radicals formed covalently bound... 

Torres MA, Dangl JL (2005) Functions of the respiratory burst oxidase in biotic interactions, abiotic stress and development. Curr Opin Plant Biol 8 397 403 Torres MA, Jones JD, Dangl JL (2006) Reactive oxygen species signaling in response to pathogens. Plant Physiol 141 373-378... 

Foley S, Curtis ADM, Hirsch A, Brettreich M, Pelegrin A, Seta P, Larroque C (2002b) Interaction of a water soluble fullerene derivative with reactive oxygen species and model enzymatic systems. Fullerenes Nanotubes and Carbon Nanostructures 10 49-67. 

Garcia-Ruiz, C., Colell, A., Paris, R., and Femandez-Checa, J. C., 2000, Direct interaction of GD3 ganghoside with mitochondria generates reactive oxygen species followed by mitochondrial permeabihty transition, cytochrome c release, and caspase activation. Faseb J14 847-858. 

Phytohormones such as ethylene, salicylic acid (SA), JA, and abscisic acid (ABA) regulate responses of plants to stresses via action referred as signaling crosstalk. Moreover, reactive oxygen species (ROS), the toxic byproducts of aerobic metabolism, play the important role of signaling molecules. Usually, the defensive responses of plants depend on the interaction (positive or negative) between phytohormone signaling pathways rather than on the independent contribution of each of them. " ... 

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