Reactive oxygen species diseases

Airway inflammation is a characteristic clinical feature of asthma. The distinction between the LAR and chronic inflammation becomes more difficult as the disease progresses. Infiltrated leukocytes release ototoxic mediators such as reactive oxygen species (ROS) and cationic (basic) proteins causing epithelial damage and cyfo/cmas that perpetuate the inflammation. Sustained inflammation leads to airway hyperrespon-siveness and airway remodeling. 

ROS, reactive oxygen species AHR, airway hyperresponsiveness MMP, matrix metalloprotease. Correlates with cough and chronic bronchitis. bNumber increases with disease severity. 

In the last few decades, several epidemiological studies have shown that a dietary intake of foods rich in natural antioxidants correlates with reduced risk of coronary heart disease particularly, a negative association between consumption of polyphenol-rich foods and cardiovascular diseases has been demonstrated. This association has been partially explained on the basis of the fact that polyphenols interrupt lipid peroxidation induced by reactive oxygen species (ROS). A large body of studies has shown that oxidative modification of the low-density fraction of lipoprotein (LDL) is implicated... 

The protective effects of carotenoids against chronic diseases appear to be correlated to their antioxidant capacities. Indeed, oxidative stress and reactive oxygen species (ROS) formation are at the basis of oxidative processes occurring in cardiovascular incidents, cancers, and ocular diseases. Carotenoids are then able to scavenge free radicals such as singlet molecular oxygen ( O2) and peroxyl radicals particularly, and protect cellular systems from oxidation. 

Van der Vliet, A. and Bast, A. (1992). Role of reactive oxygen species in intestinal diseases. Free Rad. Biol. Med. 12, 499-513. 

Cancer is one of the diseases in which a role has been implicated (see Table 13.1) for free radicals. Comprehensive accounts of the involvement of reactive oxygen species in human diseases may be found in Halliwell and Gutteridge (1989), Aruoma (1993) and in Cheeseman and Slater (1993). 

Botrytis cinerea is responsible for gray mold disease in more than 200 host plants. This necrotrophic fungus displays the capacity to kill host cells through the production of toxins and reactive oxygen species and the induction of a plant-produced oxidative burst. Thanks to an arsenal of degrading enzymes, B. cinerea is then able to feed on various plant tissues (Choquer and others 2007). 

The above data suggest an important role of reactive oxygen species in the development of heart diseases. This suggestion has been supported by many studies, which also demonstrated a potential efficacy of antioxidants, free scavengers, and chelators in the treatment of these diseases. Mitochondrial oxygen radical overproduction can probably be one of the critical causes. 

Chappie, L. 1997. Reactive oxygen species and antioxidants in inflammatory diseases. Journal of Clinical Peri-odontology 24(5), 287-296. 

The toxicity of C60 has been found to be related to its ability to cause oxidative stress (Oberdorster, 2004 and Sayes et al., 2005, 2007). However, literature describing the toxicity of C60 is contradictoiy. The first report on C60 cytotoxicity originated from Tsuchiya et al. who found that C60 inhibited cell proliferation and differentiation dose-dependently in mouse midbrain cells treated at -400 pg/ml for six days. Tsuchiya et al. proposed that reactive oxygen species (ROS) contributed to C60 cytotoxicity. The ROS generation and embryo head abnormalities suggested that C60 may contribute to brain and neuronal diseases such as Down syndrome, Alzheimer s, and Parkinson s disease (Tsuchaiya, 1996). The research that... 

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