Randomized control studies

Castro A, Suarez D, Inglada L, CarbaUo E, Dominguez A, Diago M, Such J, Del Olmo JA, Perez-Mota A, Pedreira J, Quiroga JA, Carreno V (1997) Multicenter randomized, controlled study of intramuscular administration of interferon-beta for the treatment of chronic hepatitis C. J Interferon Cytokine Res 17 27-30... 

Schrader, E. (2000). Equivalence of St John s Wort extract (Ze 117) and fluoxetine a randomized, controlled study in mild-moderate depression. Int. Clin. Psychopharmacol., 15, 61-8. 

Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A and Ylieff M (1986). Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurolo-gica Scandinavica, 73, 136-140. 

Wong WM, Gu Q, Lam SK, Fung FM, Lai KC, Hu WH, Yee YK, Chan CK, Xia HH, Yuen MF, Wong BC Randomized controlled study of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple therapy as second-line treatment for Helicobacter pylori infection. Aliment Pharmacol Ther 2003 17 553-560. 

An antibiotic association was used in an Italian randomized controlled study in which metronidazole 250 mg... 

De Leo V, la Marca A, Morgante G, Lanzetta D, Setacci C, Petraglia F (2001) Randomized control study of the effects of raloxifene on serum lipids and homocysteine in older women. Am J Obstet Gynecol 184 350-353. 

Gammans, R.E., Stringfellow, J.C., Hvizdos, A.J., Seidehamel, R.J., Cohn, J. B., Wilcox, C.S., Fabre, L.F., Pecknold, J. C Smith, W.T. and Rickels, K. (1995) Use of buspirone in patients with generalized anxiety disorder and coexisting depressive symptoms. A meta-analysis of eight randomized, controlled studies. Neuropsychobiology, 25, 193-201. 

The Canadian Task Force categorized the quality of evidence based on the type of research study. The quality of evidence was organized into three classes Class I evidence comes from procedures having at least one randomized controlled study to support them. Class II is divided into three subclasses, where II-l involves a well-designed controlled study without randomization. Class II-2 evidence comes from well-designed cohort or case-control studies, preferably carried out at more than one research setting. Class II-3 involves uncontrolled research with dramatic results (e.g., penicillin trials in the 1940s). Class III evidence includes the opinions of experts and authorities in the field based on clinical... 

Kreuter A, Sommer A, Hyun J, Brautigam M, Brockmeyer NH, Altmeyer P, Gambichler T. (2006) 1% pimecrolimus, 0.005% calcipotriol, and 0.1% betamethasone in the treatment of intertriginous psoriasis A double-blind, randomized controlled study. Arch Dermatol 142 1138-1143. 

FokM, Sham JS, Choy D, Cheng SW, Wong J. Postoperative radiotherapy for carcinoma of the esophagus a prospective, randomized controlled study. Surgery 1993 113(2) 138-147. 

Hybrid trial designs also have been used under certain circumstances. These generally combine elements of both historical and randomized control studies. They may be of particular interest if a substantial amount of control data are already available in the literature. Under such circumstances, a smaller proportion of the trial participants serve as control, whereas the majority of participants form the test group. 

Furtado RNV, Oliveira LM, Natour J. Polyarticular cor-ticostroid injection versus systemic administration in treatment of rheumatoid arthritis patients a randomized controlled study. J Rheumatol 2005 32 1691-8. 

The effects of P-adrenergic blockade on the consolidation of traumatic memories has been an area of special interest for the treatment of posttraumatic stress disorder (PTSD), and recently the first randomized controlled study on the effects of propranolol in the prevention of PTSD was published. Pittmann and coworkers (2002) could demonstrate that propranolol may reduce PTSD... 

There is strong evidence that bipolar disorder is associated with SUD in adolescents (Wilens et ah, 1999) and that pharmacological interventions are an effective treatment for youth with SUD and bipolar disorder. Two studies, including one randomized controlled study, have reported that mood stabilizers, specifically lithium and valproic acid (Depakote), significantly reduced substance use in bipolar youth (Donovan and Nunes, 1996 Geller et ah, 1998). In addition, these agents are considered effective agents for the treatment... 

TABLE 49.1 Randomized Controlled Studies of Stimulants in Preschool-Aged Children... 

In 1970, the Task Force for Evaluation of Children s Behaviors was established. This task force conducted several randomized controlled studies on drugs for children with developmental and behavioral disorders, including mental retardation and autism. The majority of such studies, however, yielded negative results. 

The Rating Fist for Evaluating Abnormal Behaviors in Children, consisting of 258 items rated on a 4-point scale, was the first original Japanese rating scale for children. It showed satisfactory sensitivity and specificity to distinguish between normal and behavior-disordered children (Fujita et ah, 1982). This scale was used in several randomized controlled studies of drugs for behavioral problems in children with autism and/... 

Aarsland D, Laake K, Larsen JP, et al Donepezil for cognitive impairment in Parkinson s disease a randomized, controlled study. J Neurol Neuro-surg Psychiatry 72 708-712, 2002... 

Davis, G.L., L.A. Balart, E.R. Schiff, et al.. Treatment of chronic hepatitis C with recombinant interferon alfa a multicenter randomized controlled study. New Engl J Med, 1989.321 1501-6. 

There have unfortunately been very few systematic examinations of treatment of benzodiazepine misuse or dependence in the illicit drug population, and knowledge on the subject has been rather static over the last decade or so. When special programmes are tried the difficulties which seem inherent in this area are still apparent, such as in the randomized controlled study of reducing benzodiazepine dosing and cognitive behavioural therapy versus standard treatment by Vorma et al. (2002). The subjects were outpatients in clinics... 

Chrubasik S, Kunzel O, Model A, Conradt C, Black A. Treatment of low back pain with a herbal or synthetic anti-rheumatic a randomized controlled study. Willow bark extract for low back pain. Rheumatology 2001 40 1388-1393. 

Pahwa R et al Ropinirole 24-hour prolonged release Randomized, controlled study in advanced Parkinson disease. Neurology 2007 68 1108. [PMID 17404192]... 

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