Raf-1 kinase inhibitor protein

Baritaki, S., Katsman, A., Chatterjee, D., Yeung, K.C., Spandidos, D.A., and Bonavida, B. (2007b). Regulation of tumor cell sensitivity to TRAlL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation. J. Immunol. 179, 5441-5453. 

Fu, Z., Kitagawa, Y, Shen, R., Shah, R., Mehra, R., Rhodes, D., Keller, P.J., Mizokami, A., Dunn, R., Chinnaiyan, A.M., et al. (2006). Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer. Prostate. 66, 248-256. 

Schuierer, M.M., BataiUe, F., Hagan, S., Kolch, W., and Bosserhoff, A.K. (2004). Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extraceUular signal-regulated kinase signaling in melanoma cell lines. Cancer Res. 64,5186-5192. 

B., Wyche, J., Kolch, W, and Sedivy, J.M. (2001). Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAKl and inhibits NF-kappaB activation. Mol. Cell Biol. 21, 7207-7217. 

Lorenz K, Lohse MJ, Quitterer U (2003) Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature 426(6966) 574-579... 

Raf-l kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine binding protein (PEBP) family, a highly conserved group of proteins found in a... 

Hagan, S., Al-Mulla, F., Mallon, E., Oien, K., Perrier, R., Gusterson, B., Garcia, J.J., and Kokh, W. (2005). Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin. Cancer Res. 11, 7392-7397. 

Minoo, P., Zlobec, I., Baker, K., Tornillo, L., Terracciano, L., Jass, J.R., andLugli, A. (2007). Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer. Am. J. Clin. Pathol. 127, 820-827. 

Cell-permeable ATP-competitive inhibitor of Raf kinase activity. Also a potent inhibitor of a variety of other protein kinases. 

Cannabinoids have been shown to induce cell cycle arrest in breast carcinoma (De Petrocellis et al. 1998), prostate carcinoma (Melck et al. 2000) and thyroid epithelioma cells (Bifulco et al. 2001). In breast carcinoma cells this has been ascribed to the inhibition of adenylyl cyclase and the cAMP/protein kinase A (PKA) pathway (Table 1). PKA phosphorylates and inhibits Raf-1, so cannabinoids prevent the inhibition of Raf-1 and induce prolonged activation of the Raf-l/MEK/ERK signalling cascade (Melck et al 1999). Cannabinoid-induced inhibition of thyroid epithelioma cell proliferation has been attributed to the induction of the cyclin-dependent kinase inhibitor p27 P (Portella et al. 2003). 

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