Quinone reductase induction

Quinone reductase induction. Acetonitrile extract of the dried root, in cell culture at a concentration of 7.9 mg/g, was active on Hematoma-Mouse-lClC7. The sample was assayed for the induction of detoxifying enzymes that may have anticarcinogenic activity . 

Su, B.-N. et al. Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay, Phytochemistry, 63, 335, 2003. 

Activity-monitored fractionation of a chloroform-soluble extract of Deprea subtriflora using a quinone reductase induction assay led to the C-18 norwithanolides mentioned previously. Six of the active compounds obtained from this plant (44, 46, 47, 49, 52 and 53), presentes an a,P-unsaturated ketone unit in ring A. Compound 55 -with a doubly unsaturated ring A ketone- was found to be inactive in the QR assay, while compound 54 was active [72]. It has been suggested that the presence of an a,p-unsaturated ketone unit in ring A of withanolides is important for inducing activity in the cell-based QR induction assay,... 

Misico RI, Song LL, Veleiro AS, Cirigliano AM, Tettamanzi MC, Burton G, Bonetto GM, Nicotra VE, Silva GL, Gil RR, Oberti JC, Kinghom AD, Pezzuto JM (2002) Induction of Quinone Reductase by Withanolides. J Nat Prod 65 677... 

Bianco NR, Chaplin LJ, Montano MM. 2005. Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage. Biochem J 385 279-287. 

Hsieh TC, Lu X, Wang Z, Wu JM. 2006. Induction of quinone reductase NQOl by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2. Med Chem 2 275-285. 

Similarly, it has been shown that consumption of cruciferous vegetables is associated with a lower incidence of cancers. Induction of phase II enzymes such as the glutathione S-transferase (GST) and quinone reductase (QR) have been demonstrated in broccoli, cabbage, and brussel sprouts. Many natural isothiocyanates derived from cruciferous vegetables and some fruits have been shown to cause induction of phase II enzymes in cultured cells and rodents. 

Favreau LV, Pickett CB. 1993. Transcriptional regulation of the rat NAD(P)H quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecoylphorbol 13-acetate. J Biol Chem 268 19875-19881. 

Yu, S.J., Quinone reductase of phytophagous insects and its induction by allelochemicals, Comp. Biochem. Physiol., 87B, 621,1987b. 

They increase the metabolic clearance of potential carcinogens and their metabolites, by the induction of glutathione S-transferases and quinone reductases. 

Gordon, G.B., Prochaska, H.J., and Yang, L.Y., Induction of NAD(P)H quinone reductase in human peripheral blood lymphocytes. Carcinogenesis, 12, 2393-2396, 1991. 

Tawfiq, N., Wanigatunga, S., Heaney, R.K., Musk, S.R., Williamson, G. and Fenwick, G.R. 1994. Induction of the anti-carcinogenic enzyme quinone reductase by food extracts using murine hepatoma cells. Fur. J. Cancer Prev. 3 285-292. 

Induction of the phase-II enzyme, quinone reductase, by withanolides and nor-withanolides from solanaceous species 04MI37. 

Casalino E, Calzaretti G, Landriscina M, Sblano C, Fabiano A, Landriscina C (2007) The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats comparison with the toxic effect on NAD(P)H quinone reductase. Toxicology 237(l-3) 24-34. doi 10.1016/j. tox.2007.04.020... 

Uda, Y., Price, K. R., Williamson, G., and Rhodes, M. J. (1997) Induction of the anti-carcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids. Cancer Lett. 120, 213-216. 

The assays based on tumor initiation events include the inhibition of DMBA-induced mutagenicity with Salmonella typhimurium strain of bacteria and the induction of quinone reductase in cultivated HeLa cells. The compounds that are inhibitors of DMBA-induced mutagenicity bioassays with Salmonella typhimurium also inhibit preneoplastic lesion formation in mammary organ culture. The induction of quinone-reductase in HeLa cells may indicate cancer chemoprevention activity [29]. 

Induction of quinone reductase with cultured Hepa lclc7 cells. A second assay we utilize... 

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