Enzymes quinone reductase

Clbacron blue dependent enzymes Quinone reductases... 

Chang, L.C. et ah. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase, J. Nat. Prod., 60, 869, 1997. 

Tawfiq, N., Wanigatunga, S., Heaney, R.K., Musk, S.R., Williamson, G. and Fenwick, G.R. 1994. Induction of the anti-carcinogenic enzyme quinone reductase by food extracts using murine hepatoma cells. Fur. J. Cancer Prev. 3 285-292. 

Induction of the phase-II enzyme, quinone reductase, by withanolides and nor-withanolides from solanaceous species 04MI37. 

Uda, Y., Price, K. R., Williamson, G., and Rhodes, M. J. (1997) Induction of the anti-carcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids. Cancer Lett. 120, 213-216. 

Su Bao-Ning, Gu JQ, Kang YH, Park EJ, Pezzuto JM, Kinghom AD (2004) Induction of the phase II enzyme, quinone reductase, by withanolides and norwithanolides from solanaceous species. Mini Rev Org Chem 1 115-123... 

Jang D.S., Park E.J., Hawthorne M.E., Vigo J.S., Graham J.G., Cabieses F., Santarsiero B.D., Mesecar A.D., Fong H.H.S., Mehta R.G., Pezzuto J.M., Kinghorn A.D. Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase. Journal... 

The antioxidant system in humans is a complex network composed by several enzymatic and nonenzymatic antioxidants. In addition to being an antioxidant, lycopene also exerts indirect antioxidant properties by inducing the production of cellular enzymes such as superoxide dismutase, glutathione S-transferase, and quinone reductase that also protect cells from reactive oxygen species and other electrophilic molecules (Goo and others 2007). 

Vella F, Ferry G, Delagrange P, et al. NRH quinone reductase 2 an enzyme of surprises and mysteries. Biochem Pharmacol 2005 71(1-2) 1-12. 

This enzyme [EC 1.6.99.2] (also known as NAD(P)H quinone reductase, DT diaphorase, quinone reductase, azoreductase, phylloquinone reductase, and menadione reductase) catalyzes the reaction of NAD(P)H with an acceptor to produce NAD(P) and the reduced acceptor. This FAD-dependent enzyme is inhibited by dicoumarol. 

Quinone reductase induction. Acetonitrile extract of the dried root, in cell culture at a concentration of 7.9 mg/g, was active on Hematoma-Mouse-lClC7. The sample was assayed for the induction of detoxifying enzymes that may have anticarcinogenic activity . 

Little information about the mechanism of action of flavonoids is anticipated from in vivo studies. The mechanism of catechin and morin seems to be related to an increase of the activity of detoxifying enzymes like glutathione-S-transferase and NADPH quinone reductase [198, 211]. Similarly, EGCG effect at the colonic level is associated to an increase in tissue superoxide dismutase levels, suggesting that it may act through a potentiation of the antioxidative defense [210]. 

Similarly, it has been shown that consumption of cruciferous vegetables is associated with a lower incidence of cancers. Induction of phase II enzymes such as the glutathione S-transferase (GST) and quinone reductase (QR) have been demonstrated in broccoli, cabbage, and brussel sprouts. Many natural isothiocyanates derived from cruciferous vegetables and some fruits have been shown to cause induction of phase II enzymes in cultured cells and rodents. 

The ubiquinone reductase activity of their low molecular weight dehydrogenase led Pharo et al. (64, 75) to conclude that the enzyme represented the mitochondrial NADH-ubiquinone reductase. However, it has been shown that the quinone reductase activity of the low molecular weight dehydrogenase is different from that of intact respiratory particles or complex I in many important respects, including kinetic constants, re-... 

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