Quinine gluconate

QuinidJne. Quinidine, an alkaloid obtained from cinchona bark (Sinchona sp.), is the dextrorotatory stereoisomer of quinine [130-95-0] (see Alkaloids). The first use of quinidine for the treatment of atrial fibrillation was reported in 1918 (12). The sulfate, gluconate, and polygalacturonate salts are used in clinical practice. The dmg is given mainly by the oral (po) route, rarely by the intravenous (iv) route of adniinistration. It is the most frequentiy prescribed po antiarrhythmic agent in the United States. The clinical uses of quinidine include suppression of atrial and ventricular extrasystoles and serious ventricular arrhythmias (1 3). 

Cinchona alkaloids quinidine gluconate injection quinine sulfate... 

Quinine Quinine, molecular formula C20H24N2O2, is a white crystalline quinoline alkaloid, isolated from Cinchona hark Cinchona succirubra), and is well known as an antimalarial drug. Quinine is extremely bitter, and also possesses antipyretic, analgesic and anti-inflammatory properties. While quinine is stiU the drug of choice for the treatment of Falciparum malaria, it can be also used to treat nocturnal leg cramps and arthritis. Quinine is an extremely basic compound, and is available in its salt forms, e.g. sulphate, hydrochloride and gluconate. 

Calcium D-galactonate, I, 70 Calcium D-gluconate, III, 141, 142, 149, 152, 155, 156, 161 IV, 331 Calcium hypochlorite, III, 165 Calcium 2-keto-D-gIuconate, III, 148, 155 Calcium 5-keto-D-gluconate, III, 156 Calcium lactobionate, calcium bromide double salt, III, 155 Calcium Ievulinate, IV, 311 Calcium maltobionate, III, 161 Calcium D-mannonate, III, 152 Calcium pectate, I, 334 Calcium D-rhamnonate, III, 144 Calcium salts, in preparation of aldonic acids with NaCN, I, 23 Calcium vicianobionate, III, 154 Calcium D-xylonate, III, 155 Camphor, optically active, formed from inactive (racemic) camphor carboxylic acid in the presence of quinine, quinidine or nicotine, V, 53 Camphor carboxylic acid. See Camphor. Camphor, 3-hydroxy-, IV, 89 Camphorquinone, phytochemical reduction of, IV, 89... 

In P. falciparum (chloroquine-resistant) infections, a dose of 750 mg mefloquine followed by 500 mg 12 hours later is recommended. The pediatric dose of mefloquine is 15 mg/kg (<45 kg) followed by 10 mg/kg 8 to 12 hours later.Intravenous quinidine gluconate followed by oral quinine should be administered for severe illness, as already indicated.A second drug needs to be administered in chloroquine-resistant P. falciparum, and this second drug should follow the oral quinidine regimen either a single dose of three tablets of pyrimethamine-sulfadoxine (Fansidar) on the last day of intravenous quinidine or clindamycin 900 mg three times daily for 3 to 5 days. An alternative oral treatment for chloroquine-resistant P falciparum infection in adults, especially in those with a history of seizures or psychiatric disorders, is the combination of atovaquone 250 mg and proguanil 100 mg (Malarone) (4 tablets daily... 

Quatemium-79 hydrolyzed milk protein Quatemium-79 hydrolyzed silk Quatemium-79 hydrolyzed soy protein Quatemium-79 hydrolyzed wheat protein Quinine Rapeseedamidopropyl benzyidimonium chloride Resorcinol acetate Ricinoleamidopropyl isostearylacetodimonium chloride Rutin rum albumin Semm protein Sesamidopropalkonium chloride Sesamidopropylamine oxide Silk amino acids Sodium carboxymethyl oleyl polypropylamine Sodium coco-glucoside tartrate Sodium cocoyl hydrolyzed keratin Sodium cocoyl hydrolyzed rice protein Sodium cocoyl hydrolyzed soy protein Sodium methyl lauroyl taurate Sodium PG-propyl thiosulfate dimethicone Sodium/TEA-lauroyl hydrolyzed keratin Sodium thiocyanate Soluble proteoglycan Soyamidopropyl dimethylamine gluconate Soyamidopropyl dimethylamine glycolate Soydimoniumhydroxypropyl hydrolyzed wheat protein... 

Available as crude and extracts (fluid extract, solid extract, etc.). Both red and yellow cinchonas were formerly official in U.S.P. and N.F. quinine sulfate and quinidine sulfate and gluconate are official in U.S.P. quinine hydrochloride and sulfate are also official in F.C.C. 

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