Quinidine sulfate

Buchler" (Buchler) wfm Quinidurule (Astra) Quinidine Sulfate (Alps ... 

Test dose Administer a single 200 mg tablet of quinidine sulfate or 200 mg IM quinidine gluconate to determine whether the patient has an idiosyncratic reaction. Adjust the dosage to maintain plasma concentration between 2 to 6 mcg/mL. 

Transferring to mexiletine When transferring from other Class I oral antiarrhythmics to mexiletine, based on theoretical considerations, initiate with a 200 mg dose, and titrate to response as described above, 6 to 12 hours after the last dose of quinidine sulfate, 3 to 6 hours after the last dose of procainamide, 6 to 12 hours after the last disopyramide dose or 8 to 12 hours after the last tocainide dose. 

Class I, Type 1A Antiarrhythmics disopyramide disopyramide phosphate procainamide hydrochloride quinidine bisulfate quinidine gluconate quinidine sulfate... 

Oral 150, 225, 300 mg tablets, capsules Quinidine sulfate [83% quinidine base] (generic)... 

Pharmacokinetics Quinidine sulfate is rapidly and almost completely absorbed after oral administration. 

Many drugs and excipients (cephalexin monohydrate, quinidine sulfate dihydrate, ampicillin trihydrate, codeine sulfate trihydrate, morphine sulfate dihydrate, dicalcium phosphate trihydrate, raffinose pentahy-drate, lactose monohydrate) utilize water as an integral part of their crystal structure. Solids that form specific crystal hydrates tend to sorb relatively small amounts of water to their external surface below a characteristic relative humidity, when initially dried to an anhydrous... 

The effects of quinidine sulfate, 50 mg orally, an inhibitor of cytochrome CYP2D6, on the metabolism of dextromethorphan 50 mg have been studied in seven healthy volunteers in a randomized, double-blind, crossover, placebo-controlled study (24). Quinidine suppressed the conversion of dextromethorphan to dextrorphan in extensive metabolizers to the extent seen in poor metabolizers. The increased concentrations of dextromethorphan increased subjective and objective pain thresholds by 35 and 45 % respectively. This result suggests that debriso-quine/sparteine-type polymorphisms account for important differences in the effect of dextromethorphan and the balance between the analgesic effect of dextromethorphan and the hallucinogenic effect of dextrorphan. Concomitant use of quinidine or other inhibitors of CYP2D6 could... 

Barzel US. Quinidine-sulfate-induced hypoplastic anemia and agranulocytosis. JAMA 1967 201(5) 325-7. 

Quinidine also inhibits a adrenoceptors, causing vasodilatation the subsequent reflex increase in sympathetic outflow (as a result of hypotension) results in this drug having proarrhythmic effects. Quinidine can be given either via nasogastric tube (quinidine sulfate) or intravenously (i.v. quinidine gluconate). 

The adverse effects of quinidine can be divided into cardiac and non-cardiac manifestations. Depression and paraphimosis are seen in many horses treated with quinidine sulfate and resolve once treatment is discontinued. Gastrointestinal effects include flatulence, which is rarely of clinical significance, and colic and diarrhea, both of... 

Quinidine sulfate is indicated for the treatment of sustained AF while i.v. qumidine gluconate is indicated for treatment of ventricular tachycardia (Fig. 12.3, Table 12.3) and recent onset AF (<7 days duration. Table 12.3) (Gerber et al 1971, Muir et al 1990), although paroxysmal AF can convert spontaneously to sinus rhythm within 48h in the absence of treatment. The recommended regimen for use of quinidine gluconate is 1.1-2.2 mg/kg i.v. 

Figure 12.2 Electrocardiograms from a horse undergoing treatment for atrial fibrillation, (a, b) Base-apex (a) and modified base-apex (b) electrocardiograms after treatment with quinidine sulfate (330mg/kg). Ventricular tachycardia, (torsades de pointes) occurred after 40 h. (c) The horse was treated with five bolus doses of magnesium sulfate, together with intravenous propanoloi, which resulted in conversion to normal sinus rhythm with QRS prolongation, (d) Twenty-four hours after conversion, the electrocardiogram showed normal sinus rhythm without QRS prolongation.

Quinidine sulfate Atrial fibrillation 2.2 mg/kg by nasogastric tube every 2 h for six doses... 

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