Questionnaires scores

Another randomized, double-blind, placebo-controlled trial of saw palmetto for the treatment of lower urinary tract symptoms also demonstrated its usefulness in these types of conditions (18). These investigators studied 85 men, randomized to receive either saw palmetto or placebo for 6 months. Effectiveness was monitored using the I-PSS, a sexual function questionnaire and urinary flow rate. Results of these studies demonstrated that the I-PSS symptom score decreased (i.e., improved) from 16.7 to 12.3 in those subjects receiving saw palmetto, whereas the symptom score decreased from 15.8 to 13.6 in the placebo group (p = 0.038). No significant difference was noted in the quality of life component of the I-PSS. Also, no differences were noted in either the sexual function questionnaire score or peak urinary flow rate between the saw palmetto and placebo groups. This study demonstrated that saw palmetto administration for 6 months resulted in an improvement in symptoms associated with BPH but not in sexual function or peak flow rate. 

Rector TS, Tschumperlin LK, Kubo SH, et al. Clinically significant improvements in the living with heart failure questionnaire score as judged by patients with heart failure. Qual Life Res 1994 3 60-1. 

Table 3 Mean change in Leicester Cough Questionnaire score per global rating category...

A recent multicenter cohort study comparing UFE to hysterectomy has been completed by Spies et al. [109]. For UFE patients, there were significant reductions in blood loss scores and menorrhagia questionnaire scores compared to baseline (Table 10.4.3). At 12 months, a larger proportion of hysterectomy patients had improved pelvic pain. There was no difference between the two groups in the proportion of patients with improvement in urinary symptoms or pelvic pressure. Similarly, no difference between both groups was found in terms of quality-of-life scores [109]. 

Comparative studies Oral baclofen has been compared retrospectively with tizanidine as adjuvant therapy to botulinum toxin type A in the management of spasticity in children [77 ]. In 30 children with gastrocnemius spasticity, of whom 17 were treated with adjuvant oral baclofen and 13 received tizanidine, the mean Gross Motor Functional Measurement scores (77 versus 68) and caregiver questionnaire scores (70 versus 67) were higher with tizanidine than baclofen. The authors suggested that the combination of botulinum toxin type A with tizanidine is more effective and causes fewer adverse reactions than the combination of botulinum toxin type A and oral... 

A mood disorder questionnaire is completed by the patient that asks about common symptoms of bipolar disorder, problems caused by the symptoms, and family history in a yes-or-no answer format. It is then scored by the clinician. 

The International Index of Erectile Dysfunction (IIED) is the most widely used questionnaire to assess the severity of ED.10 It consists of 15 questions with 5 domains erectile function, libido, orgasmic function, sexual satisfaction, and overall satisfaction. The erectile function domain has a maximum score of 30 with a score of less than 26 indicating some degree of ED. 

Sometimes you may also see quality-of-life (QOL) data collected for your clinical trial. Quality-of-life data are collected to measure the overall physical and mental well-being of a patient. These data are usually collected with a multiple-question patient questionnaire and may be summed up into an aggregate patient score for analysis. Some commonly used quality-of-life questionnaires are the SF-36 and SF-12 Health Survey, but there are quite a few disease-specific QOL questionnaires available to clinical researchers. 

Conners Parent-Teacher Questionnaire. See descriptions above for Conners Parent Questionnaire and below for the Conners Teacher Questionnaire (TQ). The PTQ is used in conjunction with either the PQ to TQ and yields a total score only (i.e., no subscales are given). The PTQ takes about five minutes to complete and is not used pretreatment. 

Body Shape Questionnaire (BSQ) 34 items single score Self-report Cooper et al., 1987... 

Gelernter et al. (1991) compared phenelzine, alprazolam, placebo, and cognitive-behavior therapy in social phobia. In those patients receiving alprazolam, only 38% improved, based on the Marks Fear Questionnaire [Marks and Matthews 1982) scores. In this study, the mean daily dose for alprazolam was 4.2 mg. At 2-month follow-up, after discontinuation of the drug, the improvement in the alprazolam group was no longer measurable. 

Such men who are untrustworthy, soclopathlc, grossly disturbed or pathologic or have criminal history or a history of recurrent, severe or recent psychotic episodes should not be selected as volunteers and if they arrive at Edgewood, should be returned to their home station. This decision should ordinarily be made during the initial screening upon the basis of severe distortion of MMPI scores or very bizarre or unappropriate items on the history or questionnaire tests. 

Each subject who showed clear-cut improvement on the MSLT (usually to an optimal score of 20) had obtained substantial extra sleep. Furthermore, almost all of the ratings for these subjects were 1 or 2, with a remarkable increase in the ratings of peak alertness (level 1) over baseline. There was also a notable disappearance of tiredness and sleepiness after lunch. Another very important result of obtaining extra sleep was the dramatic improvement in satiated subjects mood, energy levels, and sense of well-being as indicated by daily checklists and questionnaires. On the other hand, with little or no MSLT improvement, subjective tiredness throughout the day was not reduced, nor were any of the other benefits observed. 

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