Quercetin-3-<9- -glucosid

Cermak, R., Landgraf, S., and Wolffram, S., Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum, Br. J. Nutr., 91, 849, 2004. 

Walle, T., Otake, Y., Walle, U.K., and Wilson, F.A., Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption, J. Nutr., 130, 2658, 2000. 

Terao, J., Murota, K., and Moon, J.-H., Quercetin glucosides as dietary antioxidants in blood plasma modulation of their function by metabolic conbversion, in Free Radicals in Chemistry, Biology and Medicine, Yoshikawa, T., Toyokuni, Y., Yamamoto, Y., and Naito, Y., Eds., OIAC International, London, 2000, p. 50. 

Gee, J.M., DuPont, M.S., Rhodes, M.J.C., and Johnson, I.T., Quercetin glucosides interact with the intestinal glucose transport pathway. Free Radic. Biol Med, 25, 19, 1998. 

Tephmsia purpurea Persoon Hui Mao Dou (root) Rotenone, degueline, tephrosin, rutin, quercetin glucoside.57 Used as a cordial and a stomachic, a deobstruent, emmenagogue. 

Figure 11.3.12 HPLC chromatograms of polyphenolics in Concord grape extract detected at 280 nm. (A) All polyphenolics, including anthocyanins. (B) Nonanthocyanin polyphenolics after fractionation. Peak identification 1, cis-caftaric acid 2, frans-caftaric acid 3, procyanidin B3 4, c/s-coutaric acid 5, frans-coutaric acid 6, epicatechin 7, quercetin galactoside 8, quercetin glucoside. Reproduced from Oszmianski and Lee (1990) with permission from the American Society for Enology and Viticulture.

Kamada C, da Silva EL, Ohnishi-Kameyama M, Moon JH, Terao J. 2005. Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit. Free Radic Res 39 185-194. 

Lim EK, Ashford DA, Hou B, Jackson RG, Bowles DJ. 2004. Arabidopsis glycosyl-transferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides. Biotechnol Bioeng 87 623-631. 

Ader, R, Block, M., Pietzsch, S., Wolffram, S. (2001). Interaction of quercetin glucosides with the intestinal sodium/glucose co-transporter (SGLT-1). Cancer Lett., 162, 175-180. 

Both pathways of absorption give rise to intracellular aglycone, and in fact transient intracellular free aglycone is found in rat small intestine tissue after perfusion in vitro with either quercetin glucosides"- or isoflavone. ... 

Figure 2.16 HPLC profile of flavonols of a Cabernet Sauvignon grape skins extract recorded at wavelength 360nm. (1) myricetin glucuronide, (2) myricetin gluco-side, (3) quercetin glucuronide, (4) quercetin glucoside, (5) quercetin rutinoside, (6) kaempferol glucuronide, (7) kaempferol glucoside, (8) unidentified flavonol...

Peaks 1. HMF, 2. conjugated coumaric, 3. chlorogenic, 4. chlorogenic isomer, 5. caffeic, 6. p-coumarylquinic, 7. p-coumaric, 8. phloretin xyloglucoside, 9. quercetin galactoside, 10. quercetin glucoside, 11. phloridzin, 12. quercetin xyloside, 13. quercetin arabinoside,... 

Das demonstrated that oral administration of labeled 3-0-methylcatechin to three volunteers was followed by plasma peak levels within 2 hours after administration [69]. Hollman et al. studied the absorption of different glycosides of quercetin and the quercetin aglycone in nine healthy ileostomy subjects to avoid losses caused by colonic bacteria [30-31]. The absorption after oral administration decreased in the following order 52% for quercetin glucosides from fried onions > 24% for quercetin aglycone > 17% for quercetin nitinoside [31]. Consequently, humans absorb considerable amounts of quercetin, but the absorption depends on the glycosidic nature of the flavonoid [31]. 

On the other hand, the ready absorption of quercetin glucosides might be due to their hydrolyses either by the lactase phlorizin hydrolase or the cytosolic P-glycosidase in the enterocyte, although this explanation cannot be extended to all classes of flavonoids [11],... 

Day AJ, Gee JM, DuPont MS, Johnson IT, Williamson G. Absorption of quercetinS-glucoside and quercetin-4 -glucoside in the rat small intestine the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol 2003 65 1199-1206. 

Caffeic acid, chlorogenic acid,quercetin glucoside/quercetin-galactoside and phloridzin Apple pomace HSCCC Hexane-ethyl acetate-aqueous acetic acid UV, ESI -MS [73]... 

Takahama, U. Hirota, S. (2000). Deglucosidation of quercetin glucosides to the aglycone and formation of antifungal agents by peroxidase-dependent oxidation of quercetin on browning of onion scales. Plant Cell Physiology, 41,1021-1029. 

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