Quantitation screening

Hsieh Y. et al., 2001. Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 15 2481. 

Ojanpera I, Rasanen, I, Vuori E. 1991. Automated quantitative screening for acidic and neutral drugs in whole blood by dual-column capillary gas chromatography. J Anal Toxicol... 

Hsieh, Y., Chintala, M., Mei, H., Agans, J., Brisson, J. M., Ng, K., and Korfmacher, W. A. (2001). Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma [by] using fast-gradient liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 15 2481-2487. 

As stated in other papers, catalysts optimisation can be accelerated by applica-tion of ECIRT as a quantitative screening tool [12]. 

Fractional replicate designs Categorical/qualitative and quantitative Screening of factors... 

Guidelines for qualitative and quantitative screening of organic pollutants in water supplies [125] Quantitative analysis of volatile organic compounds by GC-MS [126]... 

Deventer K, Delbeke FT (2003) Validation of a quantitative screening method for corticosteroids by liquid chromatography tandem mass spectrometry. In Shanzer W, GeyerH, Gotzmann A, Mareck U (eds) Recent advances in doping analysis, vol 11, Spert and Buch Straub, Koln,... 

The gas chromatography (GC) tracing allows a fast qualitative and quantitative screening of the components of the fraction of interest. Identification of the components and a percentage evaluation provides highly specific information about the expected purity of the olive oil. 

In practice, one is often faced with choosing a model that is easily interpretable but may not approximate a response very well, such as a low-order polynomial regression, or with choosing a black box model, such as the random-function model in equations (l)-(3). Our approach makes this blackbox model interpretable in two ways (a) the ANOVA decomposition provides a quantitative screening of the low-order effects, and (b) the important effects can be visualized. By comparison, in a low-order polynomial regression model, the relationship between input variables and an output variable is more direct. Unfortunately, as we have seen, the complexities of a computer code may be too subtle for such simple approximating models. 

Semi-quantitative Screening in Agar-plate Formats 1161... 

A number of particular semi-quantitative screening methods in agar-plate formats depend on the secretion of (hydrolytic) enzymes. Clones that secrete active enzymes produce a so-called halo , i.e. a zone of clearing in turbid solid growth medium with suspended substrate. In many cases the size of the halo is a good measure for the amount of enzymatic activity released by the growing colony. 

Janes, LE., Lowendahl, A.C. and Kazlauskas, R.J. (1998) Quantitative screening of hydrolase libraries using pH... 

Mass spectrometry (MS) is playing an increasingly visible role in the molecular characterization of combinatorial libraries, natural products, drug metabolism and pharmacokinetics, toxicology and forensic investigations, and proteomics. Toward this end, electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photo-ionization (APPI) have proven valuable for both qualitative and quantitative screening of small molecules (e.g., pharmaceutical products) [9-14]. 

Tran TC, Sneed B, Haider J, Blavo D, White A, Aiyejorun T, Baranowski TC, Rubinstein AL, Doan TN, Dingledine R, Sandberg EM. Automated, quantitative screening assay for an-tiangiogenic compounds using transgenic zebraflsh. Cancer Res. 2007 67 11386-11392. 

The post-colunm infusion setup has been widely applied in matrix effects studies, e.g., in developing methods for the quantitative screening of drag discovery compoimds by fast-gradient (1 min ran time) LC-MS [83-85], in the optimization of the sample pretreatment in the analysis of methadone, comparing four off-hne and three on-hne sample pretreatment methods [77], and in evaluating various protein precipitating additives [86],... 

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