Quantitative high-throughput screening

The development of quantitative high-throughput screening (qHTS) paradigms that provide concentration-response curves for large chemical libraries in a... 

Inglese, J. et al. 2006. Quantitative high-throughput screening a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. USA 103, 11473-11478. 

Xia, M. et al. 2008. Compound cytotoxicity profiling using quantitative high-throughput screening. Envir. Health Perspect. 116, 284—291. 

Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. Compound cytotoxicity profiling using quantitative high throughput screening. Environ. Health Perspect. 2008 116 284-291. 

Austin CP, Inglese J, Simeonov A. Compound management for quantitative high-throughput screening. J. Assoc. Lab. Automat. 2008 13 79-89. 

CP, Sidransky E. Three classes of glucocerebrosidase inhibitors 48. identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc. Natl. Acad. Sci. U.S.A. 2007 104 13192-13197. 

Xia, M., Huang, R., Witt, K. L., Southall, N., Fostel, J., Cho, M. H., et al. (2008). Compound cytotoxicity profiling using quantitative high-throughput screening. Environmental Health Perspect, 116,... 

Huang, R. Southall, N. Cho, M. H. Xia, M. Inglese, J. Austin, C. P. Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem. Res. Toxicol. 2008, 21, 659-667. 

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