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Pyruvate dehydrogenase phosphatase

Fig. 14.2. Regulation of the pyruvate dehydrogenase complex (PDC) from adult A suum muscle. PDC, pyruvate dehydrogenase complex E1, pyruvate dehydrogenase subunit of the PDC PDK, pyruvate dehydrogenase kinase PDP, pyruvate dehydrogenase phosphatase. Fig. 14.2. Regulation of the pyruvate dehydrogenase complex (PDC) from adult A suum muscle. PDC, pyruvate dehydrogenase complex E1, pyruvate dehydrogenase subunit of the PDC PDK, pyruvate dehydrogenase kinase PDP, pyruvate dehydrogenase phosphatase.
Chen, G., Wang, L., Liu, S., Chuang, C. and Roche, T.E. (1996) Activated function of the pyruvate dehydrogenase phosphatase through Ca2+-facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase. Journal of Biological Chemistry 271,28064-28070. [Pg.288]

Huang, B., Gudi, R., Wu, P., Harris, R.A., Hamilton, J. and Popov, KM. (1998a) Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Journal of Biological Chemistry 273, 17680-17688. [Pg.288]

Song, H. and Komuniecki, R. (1994) Novel regulation of pyruvate dehydrogenase phosphatase purified from anaerobic muscle mitochondria of the adult parasitic nematode, Ascaris suum. Journal of Biological Chemistry 269, 31573-31578. [Pg.291]

Yang, D., Gong, X., Yakhnin, A. and Roche, T.E. (1998) Requirements for the adaptor protein role of dihydrolipoyl acetyltransferase in the up-regulated function of the pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. Journal of Biological Chemistry 273, 14130-14137. [Pg.291]

Regulation of the Pyruvate Dehydrogenase Complex In animal tissues, the rate of conversion of pyruvate to acetyl-CoA is regulated by the ratio of active, phosphory-lated to inactive, unphosphorylated PDH complex. Determine what happens to the rate of this reaction when a preparation of rabbit muscle mitochondria containing the PDH complex is treated with (a) pyruvate dehydrogenase kinase, ATP, and NADH (b) pyruvate dehydrogenase phosphatase and Ca2+ (c) malonate. [Pg.630]

The regulatory role of calcium ions in intermediary metabolism is well documented. Calcium has been shown to be involved in activation or inhibition of specific enzyme systems [105], For example, it activates cyclic nucleotide phosphodiesterase, phosphofructokinase, fructose 1 6 biphosphatase, glycerol phosphate dehydrogenase, pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase. Calcium ions inhibit pyruvate kinase, pyruvate carboxylase, Na+/K+-AT-Pase and adenylate cyclase. [Pg.83]

PDK activity is enhanced by increases in the ratios of NADH/NAD+ or acetyl-CoA/CoA and is inhibited by pyruvate or ADR Pyruvate dehydrogenase phosphatase (PDP) catalyzes the dephosphorylation of Ela and activates the PDC. [Pg.80]

Pyruvate dehydrogenase phosphatase (PDH) assay was determined using the method of Caro (1). The effects of selected experimental agents in stimulating the insulin-dependent enzyme PDH at 100 and 0.1 p,M, 1.0 and 10pM are provided in Tables 1 and 2, respectively. [Pg.307]

Lamer, J., Huang, L.C., Schwartz, C.EW., Oswald, A.S., Shen, T.-Y., Kinter, M., Tang, G., and Zeller, K., 1988, Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galatosamine and D-chiroinositol. Biochem. Biophys. Res. Commun. 151 1416-1426. [Pg.20]

B. Huang, R. Gudi, P. Wu, R.A. Harris, J. Hamilton, and K.M. Popov. 1998. Isoenzymes of pyruvate dehydrogenase phosphatase DNA-derived amino acid sequences, expression, and regulation J. Biol. Chem. 273 17680-17688. (PubMed)... [Pg.732]

See also Pyruvate Dehydrogenase Kinase, Pyruvate Dehydrogenase Phosphatase... [Pg.425]

Hucho, R Randall, D.D. Roche, T.E. Burgett, M.W. Pelley, J.W. Reed, L.J. a-Keto acid dehydrogenase complexes. XVII. Kinetic and regulatory properties of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase from bovine kidney and heart. Arch. Biochem. Biophys., 151, 328-340 (1972)... [Pg.394]

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