Pyridyl phenol

Trimethylene-2,2 -bi-l,8-naphthyridine with [Re(CO)5Br] in heptane gives the bidentately coordinated complex 27 (960M3463). Compounds of the same composition, [Re(CO)3(LL)Cl] (LL = 3,3,-dimethylene-2,2,-biquinoline) can be prepared similarly (94IC2341). / -(2,6-di-2-pyridyl-4-pyridyl)phenol reacts with [Re(CO)5Cl] and forms complex 28 with bidentate coordination of the ligand (92JPP(A)259). The product is active in the electro- and photochemical reduction of carbon dioxide. Species [Re(CO)3(2,7-bis(2,-pyridyl)-l,8-naphthyridine)Br] is known (83ICA(76)L29). 

EUP373531] were prepared from 2-(2-piperidyl)cyclohexenol, 2-(hexahydro- or tetrahydro-2-pyridyl)phenols, and 8-hydroxymethylperhy-droquinolines on treatment with aldehydes (76BCJ837 79JHC21 90EUP373531) or with a form of formaldehyde. 

A larger series of strained 2-pyridyl phenol was prepared providing a reservoir of potential stable atropisomers (98JOC6886). Coupling of the (S)-(+) bromo pyridine 279 that has been obtained by chiral HPLC led to an (S,S) tetradentate ligand 280 of known configuration (00TL7723). 

Diethy lamino-4-(5-( 1 -methyl-2-piperidinyl)-2-pyridyl]phenol, D-00323... 

PROTECTION FOR PHENOLS AND CATECHOLS 24. 4-Picolyl Ether ArOCH2-4-pyridyl (Chart 4) Formation /Cleavage ... 

A special type of ammonio group is represented by 4-( 1 -pyridinium)-pyridine and other azinium analogs. Such products often result from self-quaternization of highly reactive derivatives. A -(4-Pyridyl)-and A -(3-nitro-4-pyridyl)-pyridinium chloride hydrochlorides (121) react with aniline, chloride ion, and water to give 4-substituted pyridines plus pyridine. l-(2-Quinolyl)- and l-(4-quinolyl)-pyridinium salts undergo 2- and 4-substitution, respectively, with amines, anilines, hydroxylamine, phenols, alkoxides, mercaptans, and chloride... 

Reaction of 9-bromo-2-morphohno-4//-pyrido[l, 2-n]pyrimidin-4-ones with 4-vinylpyridine in DMF at 80 °C for 16 h in the presence of CS2CO3 and PdCbCdppf), and with amines and phenols in boiling THF for 20 h in the presence of KOr-Bu and PdCbCdppf) yielded 9-[2-(4-pyridyl)vinyl), 9-(substituted amino), and 9-aryloxy derivatives, respectively (01MIP9). 4-Hydroxyaniline gave a 9-(4-hydroxyphenyl)amino derivative. 

A tetradentate ligand 2- bis[2-(2-pyridyl)ethyl]aminomethyl phenolate complexes zinc with an N30 donor set including pyridyl and phenolic groups. The X-ray structure reveals that a dimeric... 

N40 donor set ligands with pyridyl and phenolic arms form mononuclear complexes with approximately trigonal-bipyramidal coordination geometries.888... 

The reaction of l-(2-pyridyl)-3,5-dinitro-2-pyridone 14 with ethyl sodio acetoacetate or diethyl sodio acetone-dicarboxylate gave a mixture of N-(2-pyridyl)nitroacetamide 15, phenol derivatives 16, and a low yield of 2-oxo-2,5-dihydropyrido[1,2-b [ 1,2,4]triazine 4-oxide 17 (79TL1393). The mechanism of the reaction is shown in Scheme 5. 

The hydrochloride of 3-amino-4-hydrazinopyridine 65 was prepared by reaction of the 4-chloro-3-nitropyridine derivative with ethoxycarbonyl-hydrazine in phenol to give the hydrochloride of ethyl 3-(3-nitro-4-pyridyl)carbazate 64 (R2 = OEt), which on successive heating in concentrated hydrochloric acid and hydrogenation over Pd/C gave 65. Its reaction with phenylacetic acid or with phenoxyacetic acid gave the hydrochloride... 

As compounds exhibiting enhancing effects on CL reactions, a variety of phenols, e.g., firefly luciferin and 6-hydroxybenzothiazole derivatives [12,13], 4-iodophe-nol [14], 4-(4-hydroxyphenyl)thiazole [15], 2-(4,-hydroxy-3 -methoxy-benzyli-dene)-4-cyclopentene-l,3-dione (KIH-201) [16], and 2-(4-hydroxyphenyl)-4,5-diphenylimidazole (HDI) and 2-(4-hydroxyphenyl)-4,5-di(2-pyridyl)imidazole (HPI)[17] (Fig. 6A), and phenylboronic acid derivatives, e.g., 4-phenylylboronic acid [18], 4-iodophenylboronic acid [19], and4-[4,5-di(2-pyridyl)-l //-imidazol-2-yl]phenylboronic acid (DPPA) [20] (Fig. 6B), in the luminol/hydrogen peroxide/peroxidase system are well known. Rhodamine B and quinine are used as sensitizers in the CL-emitting reaction between cerium (IV) and thiol compounds. This CL reaction was successfully applied to the sensitive determination of various thiol drugs [21-32],... 

Figure 6 Representative (A) phenol-type and (B) phenylboronic acid-type enhancers for luminol/hydrogen peroxide/peroxidase system. KIH-201, 2-(4 -hydroxy-3 -methoxy-benzylidene)-4-cyclopentene-1,3-dione HDI, 2-(4-hydroxyphenyl)-4,5-diphenylimida-zole HPI, 2-(4-hydroxyphenyl)-4,5-di(2-pyridyl)imidazole DPPA, 4-[4,5-di(2-pyridyl)-lH-imidazol-2-yl]phenylboronic acid).

Itoh et al. (151) employed a tetradentate amine and synthesized the complex [Znn(l)(MeCN)]PF6, where 1 represents the monoanion of 2-methylthio-4-ferf-6-[[bis[2-(2-pyridyl)ethyl]amino]methyl]phenol (see Fig. 31 for 1). This complex was chemically [with (NH4)2[Ce(N03)6]) or electrochemically oxidized yielding the (phenoxyl)zinc species Zn1 (1 )(MeCN )]PF6. It displays phenoxyl K-K tran-... 

Structural information on aromatic donor molecule binding was obtained initially by using H NMR relaxation measurements to give distances from the heme iron atom to protons of the bound molecule. For example, indole-3-propionic acid, a structural homologue of the plant hormone indole-3-acetic acid, was found to bind approximately 9-10 A from the heme iron atom and at a particular angle to the heme plane (234). The disadvantage of this method is that the orientation with respect to the polypeptide chain cannot be defined. Other donor molecules examined include 4-methylphenol (p-cresol) (235), 3-hydroxyphenol (resorcinol), 2-methoxy-4-methylphenol and benzhydroxamic acid (236), methyl 2-pyridyl sulfide and methylp-tolyl sulfide (237), and L-tyrosine and D-tyrosine (238). Distance constraints of between 8.4 and 12.0 A have been reported (235-238). Aromatic donor proton to heme iron distances of 6 A reported earlier for aminotriazole and 3-hydroxyphenol (resorcinol) are too short because of an inappropriate estimate of the molecular correlation time (239), a parameter required for the calculations. Distance information for a series of aromatic phenols and amines bound to Mn(III)-substituted HRP C has been published (240). 

Auch Phenole lassen sich an Aldimine addieren (Bd.XI/1, S. 337). Ein neueres Beispiel ist die Herstellung von 2-[Anilino-( 2-pyridyl)-methvl]-phenol aus 2-(Phenylimino-methyl)-pyridin und Phenol in siedendem Benzol2. 

Some functional groups such as phenol, pyridyl, catechol, imidazole, and amine, which are attached to the carbon atoms of macrocyclic framework, also affect the coordination geometry of the metal ions (39-44). 

Perfluoro[AT-fluoro-Af-(4-pyridyl)acetamide], prepared via direct fluorination of the sodium salt of perfluoro[/V-(4-pyridyl)acetamide], readily fluorinates diethyl sodio(phenyl)malonate, 1-morpholinocyclohexene, phenol and anisole under mild conditions.129... 

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